TUSC5 Antibody - #DF3345

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产品: TUSC5 抗体
货号: DF3345
描述: Rabbit polyclonal antibody to TUSC5
应用: WB IHC IF/ICC
反应: Human, Rat
分子量: 22 KD; 19kD(Calculated).
蛋白号: Q8IXB3
RRID: AB_2835712

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Rat
克隆:
Polyclonal
特异性:
TUSC5 Antibody detects endogenous levels of total TUSC5.
RRID:
AB_2835712
引用格式: Affinity Biosciences Cat# DF3345, RRID:AB_2835712.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Dispanin subfamily B member 1; DSPB1; Interferon-induced transmembrane domain-containing protein D3; LOST1; Protein located at seventeen p thirteen point three 1; Protein located at seventeen-p-thirteen point three 1; Tumor suppressor candidate 5; Tusc5; TUSC5_HUMAN;

抗原和靶标

免疫原:
Uniprot:

Q8IXB3(TARG1_HUMAN) >>Visit HPA database.

基因/基因ID:
TUSC5(286753)
表达:
Q8IXB3 TARG1_HUMAN:

Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825). Expressed in adipose tissue (PubMed:26629404).

序列:
MAHPVQSEFPSAQEPGSAAFLDLPEMEILLTKAENKDDKTLNLSKTLSGPLDLEQNSQGLPFKAISEGHLEAPLPRSPSRASSRRASSIATTSYAQDQEAPRDYLILAVVACFCPVWPLNLIPLIISIMSRSSMQQGNVDGARRLGRLARLLSITLIIMGIVIIMVAVTVNFTVQKK

研究背景

功能:

Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation.

细胞定位:

Cell membrane>Multi-pass membrane protein. Endomembrane system>Multi-pass membrane protein. Cytoplasm>Perinuclear region.
Note: Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus. Expressed in adipose tissue.

亚基结构:

Interacts with SLC2A4; the interaction is required for proper SLC2A4 reacycling after insulin stimulation.

蛋白家族:

Belongs to the CD225/Dispanin family.

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