PSMD2 Antibody - #DF3256

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产品: PSMD2 抗体
货号: DF3256
描述: Rabbit polyclonal antibody to PSMD2
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 100 KD; 100kD(Calculated).
蛋白号: Q13200
RRID: AB_2835636

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MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
PSMD2 Antibody detects endogenous levels of total PSMD2.
RRID:
AB_2835636
引用格式: Affinity Biosciences Cat# DF3256, RRID:AB_2835636.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; MGC14274; P97; Proteasome (prosome macropain) 26S subunit non ATPase 2; Proteasome 26S subunit, non-ATPase, 2; Proteasome 26S, subunit 2; Protein 55.11; Psmd2; PSMD2_HUMAN; Rpn1; S2; TNFR associated protein 2; TRAP2; Tumor necrosis factor receptor associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2;

抗原和靶标

免疫原:
Uniprot:

Q13200(PSMD2_HUMAN) >>Visit HPA database.

基因/基因ID:
PSMD2(5708)
表达:
Q13200 PSMD2_HUMAN:

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.

序列:
MEEGGRDKAPVQPQQSPAAAPGGTDEKPSGKERRDAGDKDKEQELSEEDKQLQDELEMLVERLGEKDTSLYRPALEELRRQIRSSTTSMTSVPKPLKFLRPHYGKLKEIYENMAPGENKRFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKVQREPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q13200 作为底物

Site PTM Type Enzyme
K8 Ubiquitination
S16 Phosphorylation
T24 Phosphorylation
K27 Ubiquitination
S29 Phosphorylation
K31 Ubiquitination
K39 Ubiquitination
K41 Ubiquitination
S46 Phosphorylation
K50 Ubiquitination
K66 Ubiquitination
R79 Methylation
K94 Ubiquitination
K97 Ubiquitination
K105 Ubiquitination
K107 Ubiquitination
Y110 Phosphorylation
K119 Ubiquitination
S134 Phosphorylation
R137 Methylation
K141 Ubiquitination
S147 Phosphorylation
Y158 Phosphorylation
K168 Ubiquitination
K178 Ubiquitination
T186 Phosphorylation
K189 Ubiquitination
Y194 Phosphorylation
Y226 Phosphorylation
K228 Ubiquitination
K286 Ubiquitination
K292 Ubiquitination
K343 Ubiquitination
Y349 Phosphorylation
K350 Acetylation
K350 Ubiquitination
R357 Methylation
S361 Phosphorylation
S363 Phosphorylation
K397 Ubiquitination
Y432 Phosphorylation
Y434 Phosphorylation
S435 Phosphorylation
S436 Phosphorylation
Y439 Phosphorylation
K441 Ubiquitination
S442 Phosphorylation
T499 Phosphorylation
S508 Phosphorylation
K551 Ubiquitination
Y554 Phosphorylation
K623 Ubiquitination
S711 Phosphorylation
K712 Ubiquitination
K754 Ubiquitination
K773 Ubiquitination
K858 Ubiquitination
K860 Ubiquitination
K902 Ubiquitination
Y906 Phosphorylation

研究背景

功能:

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.

组织特异性:

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.

亚基结构:

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2. Interacts with RPGRIP1L (By similarity). Interacts with CRY1 in a KDM8-dependent manner (By similarity).

蛋白家族:

Belongs to the proteasome subunit S2 family.

研究领域

· Genetic Information Processing > Folding, sorting and degradation > Proteasome.

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

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