NUDT1 Recombinant Rabbit mAb - #BF4453

WB 1:1000-1:5000, IHC 1:50, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

Human

Monoclonal [ReFirm23903]

NUDT1 Recombinant Rabbit mAb detects endogenous levels of NUDT1.

Unconjugated.

Affinity-chromatography.

Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Misincorporation of oxidized nucleoside triphosphates into DNA,RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates,such as 8-oxo-dGTP,8-oxo-dATP,2-hydroxy-dATP,and 2-hydroxy rATP,to monophosphates,thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm,with some in the mitochondria,suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants,some of which encode distinct isoforms,have been identified. Additional variants have been observed,but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional,longer isoform (p26) has been described.