产品: CSTF1 抗体
货号: DF3241
描述: Rabbit polyclonal antibody to CSTF1
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 48 KD; 48kD(Calculated).
蛋白号: Q05048
RRID: AB_2835621

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   规格 价格 库存
 50ul RMB¥ 1250 现货
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 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Bovine(100%), Horse(91%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(80%)
克隆:
Polyclonal
特异性:
CSTF1 Antibody detects endogenous levels of total CSTF1.
RRID:
AB_2835621
引用格式: Affinity Biosciences Cat# DF3241, RRID:AB_2835621.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CF 1 50 kDa subunit; CF-1 50 kDa subunit; Cleavage stimulation factor 50 kDa subunit; Cleavage stimulation factor 50kDa subunit; Cleavage stimulation factor; Cleavage stimulation factor subunit 1; Cleavage stimulation factor, 3 prime pre RNA, subunit 1, 50 kD; cleavage stimulation factor, 3' pre RNA, subunit 1, 50kD; cleavage stimulation factor, 3' pre RNA, subunit 1, 50kDa; CstF 50; CSTF 50 kDa subunit; CstF-50; CSTF1; CSTF1_HUMAN; CstFp50; OTTHUMP00000031332;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
序列:
MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Horse
91
Xenopus
80
Pig
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q05048 作为底物

Site PTM Type Enzyme
T63 Phosphorylation
Y67 Phosphorylation
Y195 Phosphorylation
K198 Ubiquitination
K204 Ubiquitination
K208 Ubiquitination
K287 Ubiquitination
K316 Ubiquitination
K319 Ubiquitination
K326 Ubiquitination
T364 Phosphorylation
Y367 Phosphorylation
S393 Phosphorylation

研究背景

功能:

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.

翻译修饰:

The N-terminus is blocked.

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts (via repeats WD) directly with CSTF3. Interacts (via repeat WD6) with BARD1. Interacts with ERCC6.

蛋白家族:

N-terminus mediates homodimerization.

研究领域

· Genetic Information Processing > Translation > mRNA surveillance pathway.

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