STIM1 Recombinant Rabbit mAb - #BF4282

WB 1:1000-1:5000, IHC 1:50-1:100
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

Human, Mouse, Rat

Monoclonal [ReFirm23732]

STIM1 Recombinant Rabbit mAb detects endogenous levels of STIM1.

Unconjugated.

Affinity-chromatography.

Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5,an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome,Wilms tumor,rhabdomyosarcoma,adrenocrotical carcinoma,and lung,ovarian,and breast cancer. This gene may play a role in malignancies and disease that involve this region,as well as early hematopoiesis,by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma,immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts,ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1),with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.