ALK Recombinant Rabbit mAb - #BF4210

WB 1:1000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

Human, Mouse, Rat

Monoclonal [ReFirm23657]

ALK Recombinant Rabbit mAb detects endogenous levels of ALK.

Unconjugated.

Affinity-chromatography.

Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

This gene encodes a receptor tyrosine kinase,which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain,an hydrophobic stretch corresponding to a single pass transmembrane region,and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged,mutated,or amplified in a series of tumours including anaplastic large cell lymphomas,neuroblastoma,and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene,which result in creation of multiple fusion genes in tumourigenesis,including ALK (chromosome 2),EML4 (chromosome 2),ALK,RANBP2 (chromosome 2),ALK,ATIC (chromosome 2),ALK,TFG (chromosome 3),ALK,NPM1 (chromosome 5),ALK,SQSTM1 (chromosome 5),ALK,KIF5B (chromosome 10),ALK,CLTC (chromosome 17),ALK,TPM4 (chromosome 19),and ALK,MSN (chromosome X).