RORG Antibody - #DF3196

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产品: RORG 抗体
货号: DF3196
描述: Rabbit polyclonal antibody to RORG
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse
预测: Pig, Zebrafish, Horse, Sheep, Rabbit, Dog, Xenopus
蛋白号: P51449
RRID: AB_2835555

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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WB Handbook
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IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
RORG Antibody detects endogenous levels of total RORG.
RRID:
AB_2835555
引用格式: Affinity Biosciences Cat# DF3196, RRID:AB_2835555.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

IMD42; MGC129539; NR1F3; Nuclear receptor ROR gamma; Nuclear receptor ROR-gamma; Nuclear receptor RZR gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR related orphan nuclear receptor variant 2; RAR related orphan receptor C; RAR related orphan receptor C, isoform a; RAR related orphan receptor gamma; RAR-related orphan receptor C; Retinoic acid binding receptor gamma; Retinoid related orphan receptor gamma; Retinoid-related orphan receptor-gamma; Rorc; RORG; RORG_HUMAN; RZR GAMMA; RZRG; TOR;

抗原和靶标

免疫原:

A synthesized peptide derived from human RORG, corresponding to a region within the internal amino acids.

基因/基因ID:
RORC(6097)

研究领域

· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).

· Organismal Systems > Immune system > Th17 cell differentiation.   (View pathway)

· Organismal Systems > Environmental adaptation > Circadian rhythm.   (View pathway)

文献引用

1). CYSLTR1 antagonist inhibits Th17 cell differentiation by regulating the NF-κB signaling for the treatment of psoriasis. International journal of biological sciences, 2024 (PubMed: 38617532) [IF=8.2]
2). RANK promotes colorectal cancer migration and invasion by activating the Ca2+-calcineurin/NFATC1-ACP5 axis. Cell Death & Disease, 2021 (PubMed: 33795653) [IF=8.1]
3). Chronic low-grade inflammation is involved in TLR4 knockout-induced spontaneous obesity in aged mice. BIOMEDICINE & PHARMACOTHERAPY, 2022 (PubMed: 35093760) [IF=6.9]

Application: WB    Species: Mouse    Sample:

Fig. 6. TLR4 KO affected the differentiation of Th cells in the spleen of 18 M old mice. a Relative image of the spleen and spleen index, n = 6. b Relative mRNA expression of Tbet, Gata3, Rorγt and Foxp3, n = 6. c Relative mRNA expression of important Th downstream genes in the spleen, n = 6. d Protein expression of Tbet, Gata3, Rorγt and Foxp3 and the relative Tbet, Gata3, Rorγt and Foxp3 protein levels is shown in bar graph, n = 3. e Serum levels of IL-1β, IL-6, IL-10 and TNF-α protein were measured by ELISA, n = 8. Data are presented as mean ± S.E.M.
4). RORα inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity. Cancer cell international, 2024 (PubMed: 38184549) [IF=5.8]
5). Limonin alleviates high-fat diet-induced dyslipidemia by regulating the intestinal barrier via the microbiota-related ILC3-IL22-IL22R pathway. Food & function, 2024 (PubMed: 38375746) [IF=5.1]
6). Total flavonoids of Sophora flavescens and kurarinone ameliorated ulcerative colitis by regulating Th17/Treg cell homeostasis. JOURNAL OF ETHNOPHARMACOLOGY, 2022 (PubMed: 35863614) [IF=4.8]
7). Regulatory effects of miRNA-126 on Th cell differentiation and cytokine expression in allergic rhinitis. Cellular Signalling, 2022 (PubMed: 35953026) [IF=4.4]
8). Xiao-Huang-Qu-Dan Decoction alleviates ANIT-induced cholestatic liver injury by inhibiting JAK2/STAT3 pathway and regulating TH17/Treg. Chinese Journal of Natural Medicines, 2024 [IF=4.0]

Application: WB    Species: Rat    Sample: colon tissue

Figure 8. XHQDD suppresses the JAK2/STAT3 signalling pathway in colon tissue. (A-B)Representative images of p-JAK2 and p-STAT3 protein expression in colon tissues were obtained using IHC.(C-D)The results show the mean IOD of p-JAK2 and p-STAT3 proteins stained by IHC. (E-I)JAK2, p-JAK2, STAT3, p-STAT3, RORγt, and Foxp3 protein expressions. Data are shown as means ± SD. Compared with CON group, **P < 0. 01. Compared with ANIT group, ##P < 0. 01. n = 10. Scale bar = 50 μm.
9). Bergapten attenuates sepsis-induced acute lung injury in mice by regulating Th17/Treg balance. Inhalation toxicology, 2024 (PubMed: 39420573) [IF=2.0]
10). Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay. Journal of visualized experiments : JoVE, 2023 (PubMed: 37811950) [IF=1.2]
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