SHP1 Recombinant Rabbit mAb - #BF3602

WB 1:1000, IHC 1:100
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

Human, Mouse, Rat

Monoclonal [ReFirm23049]

SHP1 Recombinant Rabbit mAb detects endogenous levels of SHP1.

Unconjugated.

Affinity-chromatography.

Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth,differentiation,mitotic cycle,and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains,which act as protein phospho-tyrosine binding domains,and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells,and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with,and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene,which encode distinct isoforms,have been reported.