S100B Recombinant Rabbit mAb - #BF3545

WB 1:1000-1:3000, IHC 1:200-1:1000, IF/ICC 1:100
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

Human, Mouse, Rat

Monoclonal [ReFirm22992]

S100B Recombinant Rabbit mAb detects endogenous levels of S100B.

Unconjugated.

Affinity-chromatography.

Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and,or nucleus of a wide range of cells,and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21,however,this gene is located at 21q22.3. This protein may function in Neurite extension,proliferation of melanoma cells,stimulation of Ca2+ fluxes,inhibition of PKC-mediated phosphorylation,astrocytosis and axonal proliferation,and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological,neoplastic,and other types of diseases,including Alzheimer's disease,Down's syndrome,epilepsy,amyotrophic lateral sclerosis,melanoma,and type I diabetes.