NLRP3 Recombinant Rabbit mAb - #BF3010

WB 1:1000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

Human, Mouse, Rat

Monoclonal [ReFirm22457]

NLRP3 Recombinant Rabbit mAb detects endogenous levels of NLRP3.

Unconjugated.

Affinity-chromatography.

Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

This gene encodes a pyrin-like protein containing a pyrin domain,a nucleotide-binding site (NBS) domain,and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD,ASC,which contains a caspase recruitment domain,and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling,and it plays a role in the regulation of inflammation,the immune response,and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS),Muckle-Wells syndrome (MWS),chronic infantile neurological cutaneous and articular (CINCA) syndrome,and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data,however,insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.