Collagen I Recombinant Rabbit mAb - #BF3008

WB 1:1000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

Human, Mouse, Rat

Monoclonal [ReFirm22455]

Collagen I Recombinant Rabbit mAb detects endogenous levels of Collagen I.

Unconjugated.

Affinity-chromatography.

Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone,cornea,dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV,Ehlers-Danlos syndrome type VIIA,Ehlers-Danlos syndrome Classical type,Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22,where this gene and the gene for platelet-derived growth factor beta are located,are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans,resulting from unregulated expression of the growth factor. Two transcripts,resulting from the use of alternate polyadenylation signals,have been identified for this gene.