TBX 2/3 Antibody - #AF0319

(2)  
产品: TBX 2/3 抗体
货号: AF0319
描述: Rabbit polyclonal antibody to TBX 2/3
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 79kDa; 79kD,75kD(Calculated).
蛋白号: O15119 | Q13207
RRID: AB_2833482

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MS Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
TBX 2/3 Antibody detects endogenous levels of total TBX 2/3.
RRID:
AB_2833482
引用格式: Affinity Biosciences Cat# AF0319, RRID:AB_2833482.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Bladder cancer related protein XHL; T box 2; T box 3; T box protein 2; T box protein 3; T box transcription factor TBX2; T box transcription factor TBX3; TBX3-ISO; UMS; XHL; FLJ10169; HGNC:11597; T box 2; T box transcription factor TBX2; T-box protein 2; T-box transcription factor TBX2; TBX2; TBX2_HUMAN;

抗原和靶标

免疫原:
Uniprot:

O15119(TBX3_HUMAN) >>Visit HPA database.

Q13207(TBX2_HUMAN) >>Visit HPA database.

基因/基因ID:
TBX2(6909) | TBX3(6926)
表达:
O15119 TBX3_HUMAN:

Widely expressed.

Q13207 TBX2_HUMAN:

Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.

描述:
TBX3 Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. 4 isoforms of the human protein are produced by alternative splicing.
序列:
MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAERPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEARALPGKEAFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSELQSIQRLVSGLEAKPDRSRSASP

MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALAKPLPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPPAREPPTSPGAAPSPLRLHRARAEEKSCAADSDPEPERLSEERAGAPLGRSPAPDSASPTRLTEPERARERRSPERGKEPAESGGDGPFGLRSLEKERAEARRKDEGRKEAAEGKEQGLAPLVVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFTMGPGAFSAMGMGHLLASVAGGGNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLASEGSKAAGGNSREPSPLPELALRKVGAPSRGALSPSGSAKEAANELQSIQRLVSGLESQRALSPGRESPK

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - O15119/Q13207 作为底物

Site PTM Type Enzyme
K104 Ubiquitination
K110 Ubiquitination
K118 Ubiquitination
T121 Phosphorylation
K127 Ubiquitination
Y163 Phosphorylation
Y185 Phosphorylation
S190 Phosphorylation
T203 Phosphorylation
K206 Ubiquitination
K208 Ubiquitination
Y265 Phosphorylation
K293 Ubiquitination
K301 Ubiquitination
K313 Ubiquitination
S371 Phosphorylation
S375 Phosphorylation
S381 Phosphorylation
S396 Phosphorylation
S400 Phosphorylation
S409 Phosphorylation
K413 Ubiquitination
S432 Phosphorylation
S435 Phosphorylation
S438 Phosphorylation
T441 Phosphorylation
S443 Phosphorylation
S444 Phosphorylation
S445 Phosphorylation
T446 Phosphorylation
S456 Phosphorylation
T462 Phosphorylation
K466 Ubiquitination
S680 Phosphorylation
S707 Phosphorylation
K714 Ubiquitination
T718 Phosphorylation
S719 Phosphorylation Q9Y243 (AKT3)
S729 Phosphorylation
K734 Ubiquitination
S738 Phosphorylation
S740 Phosphorylation
S742 Phosphorylation
Site PTM Type Enzyme
S94 Phosphorylation
Y165 Phosphorylation
K210 Ubiquitination
Y247 Phosphorylation
T252 Phosphorylation
Y253 Phosphorylation
T258 Phosphorylation
K275 Ubiquitination
K283 Ubiquitination
K295 Ubiquitination
S320 Phosphorylation
S323 Phosphorylation
S324 Phosphorylation
S336 Phosphorylation
S342 Phosphorylation
S360 Phosphorylation
S368 Phosphorylation
S379 Phosphorylation
S384 Phosphorylation
S386 Phosphorylation
T391 Phosphorylation
S401 Phosphorylation
S635 Phosphorylation
T638 Phosphorylation
S643 Phosphorylation
S646 Phosphorylation
S653 Phosphorylation
S657 Phosphorylation
S676 Phosphorylation
S705 Phosphorylation
S710 Phosphorylation

研究背景

功能:

Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Widely expressed.

亚基结构:

Interacts with PML (isoform PML-4).

功能:

Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation.

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.

亚基结构:

Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4).

蛋白家族:

The repression domain 1 (RD1) is necessary for its interaction with PML.

研究领域

· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells.   (View pathway)

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