Simtuzumab - #BF6168
产品描述
货号:
BF6168
简介:
Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab non-competitively blocks collagen cross-linking, reduces LOXL2 protein expression and attenuates extracellular matrix changes. Simtuzumab reduces myocardial fibrosis and prevents cardiac dysfunction. Simtuzumab lowers Myh7 and Nppa gene expression, reduces contraction heterogeneity, and cuts COL1A1 deposition. Simtuzumab can be used for the research of LMNA mutation-induced dilated cardiomyopathy, idiopathic pulmonary fibrosis, and primary sclerosing cholangitis.
别名:
辛妥珠单抗; AB 0024; GS 6624
靶标:
LOXL2
蛋白ID:
Q9Y4K0
基因ID:
4017
分子量:
145.5 kDa
应用:
FACS, ELISA, Functional assay
反应:
Human
CAS NO.:
1318075-13-6
运输方式:
Shipping with dry ice.
缓冲液:
Supplied as a 0.22 μm filtered solution in 100 mM Pro-Ac, 20 mM Arg, pH 5.0
储存条件:
Store at -80°C for 2 years. Aliquots should be stored at the same temperature after first use to avoid
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