MEOX2 Antibody - #DF3192

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产品: MEOX2 抗体
货号: DF3192
描述: Rabbit polyclonal antibody to MEOX2
应用: WB IHC IF/ICC
文献验证: IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 33 KD; 34kD(Calculated).
蛋白号: P50222
RRID: AB_2835415

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MS Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
预测:
Pig(100%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%), Chicken(%), Xenopus(%)
克隆:
Polyclonal
特异性:
MEOX2 Antibody detects endogenous levels of total MEOX2.
RRID:
AB_2835415
引用格式: Affinity Biosciences Cat# DF3192, RRID:AB_2835415.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

GAX; Growth arrest-specific homeobox; Homeobox protein MOX 2; Homeobox protein MOX-2; meox2; MEOX2_HUMAN; Mesenchyme homeobox 2; MOX2;

抗原和靶标

免疫原:
Uniprot:

P50222(MEOX2_HUMAN) >>Visit HPA database.

基因/基因ID:
MEOX2(4223)
表达:
P50222 MEOX2_HUMAN:

Embryo and placenta.

序列:
MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHHQQQQHQALQTNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAEKRSGGKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSIANEDSHDSDHSSEHAHL

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

功能:

Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

细胞定位:

Nucleus. Nucleus speckle.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Embryo and placenta.

亚基结构:

Interacts with RNF10.

蛋白家族:

The polyhistidine repeat may act as a targeting signal to nuclear speckles.

文献引用

1). A Crucial Angiogenesis-Associated Gene MEOX2 Could Be a Promising Biomarker Candidate for Breast Cancer. Frontiers in Oncology, 2022 (PubMed: 35615155) [IF=3.5]

Application: IHC    Species: Human    Sample: breast cancer tissues

Figure 4 MEOX2 and CD31 expression detected with IHC (A) MEOX2 expression in breast cancer tissues and adjacent normal tissues. Scale bar: 50 μm. Quantification of IHC scores (addition of intensity score and positive signal area) (n=20) (B) CD31 expression in low MEOX2 group and high MEOX2 group. Scale bar: 50 μm. Quantification of CD31-positive vessels (n=20). ***p < 0.001.

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