AFfirm™ TGFBR1 Mouse Monoclonal Antibody - #BF8256

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产品: TGFBR1 小鼠 单克隆 抗体
货号: BF8256
描述: Mouse monoclonal antibody to TGFBR1
应用: IF/ICC
文献验证: IF/ICC
反应: Human
预测: Pig, Bovine, Sheep, Rabbit, Dog, Xenopus
蛋白号: P36897

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Mouse
应用:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Monoclonal [AFfirm8256]
特异性:
TGFBR1 Mouse Monoclonal Antibody detects endogenous levels of total TGFBR1
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AAT 5; AAT5; Activin A receptor type II like kinase 53kDa; Activin A receptor type II like kinase, 53kD; Activin A receptor type II like protein kinase of 53kD; activin A receptor type II-like kinase, 53kDa; activin A receptor type II-like protein kinase of 53kD; Activin receptor like kinase 5; Activin receptor-like kinase 5; ACVRLK 4; ACVRLK4; ALK 5; ALK-5; ALK5; LDS1A; LDS2A; MSSE; Serine/threonine protein kinase receptor R4; Serine/threonine-protein kinase receptor R4; SKR 4; SKR4; TbetaR I; TbetaR-I; TGF beta receptor type 1; TGF beta receptor type I; TGF beta type I receptor; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFBR 1; TGFBR1; TGFBR1 protein; TGFR 1; TGFR-1; TGFR1; TGFR1_HUMAN; Transforming growth factor beta receptor 1; Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD); Transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); Transforming growth factor-beta receptor type I;

抗原和靶标

免疫原:

A synthesized peptide derived from human TGFBR1, corresponding to a region within the internal amino acids.

基因/基因ID:
TGFBR1(7046)
描述:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.

研究领域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Cellular Processes > Cellular community - eukaryotes > Adherens junction.   (View pathway)

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Environmental Information Processing > Signal transduction > FoxO signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > TGF-beta signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Apelin signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Hippo signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).

· Human Diseases > Infectious diseases: Viral > Hepatitis B.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Colorectal cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Pancreatic cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Chronic myeloid leukemia.   (View pathway)

· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma.   (View pathway)

· Human Diseases > Cancers: Specific types > Gastric cancer.   (View pathway)

· Organismal Systems > Development > Osteoclast differentiation.   (View pathway)

· Organismal Systems > Immune system > Th17 cell differentiation.   (View pathway)

· Organismal Systems > Endocrine system > Relaxin signaling pathway.

文献引用

1). CCN2 mediates fibroblast-macrophage interaction in knee arthrofibrosis based on single-cell RNA-seq analysis. Bone research, 2025 (PubMed: 39994205) [IF=14.3]

Application: IF/ICC    Species: human    Sample: fibroblasts

Fig. 5 Knockdown of CCN2 attenuated the pro-fibrotic functions of fibroblasts by downregulating TGFBR/SMAD signalling pathway. a, b Expression of CCN2 with siCCN2 or with siNC (non-target control siRNA) assessed by RT-qPCR and western blotting (n = 3). c–h Expression of CCN2 and other activation markers (αSMA and COL1) after culturing with TGF-β (4 ng/mL) in transfected fibroblasts analyzed by RT-qPCR and western blotting (n = 3). i Proliferations of the transfected cells measured using the CCK-8 assay at different time intervals (n = 3). j Cell migration evaluated by wound-healing assays (n = 3). Representative images (original magnification, ×40) are shown on the left. Bar = 200 μm. The migration area rates in multiple time intervals are presented on the right. k, l Expression of TGFBR1 and SMAD3 after culturing with TGF-β (4 ng/mL) in transfected fibroblasts analyzed by RT-qPCR (n = 3). m Left: Representative immunofluorescence images of TGFBR1 and SMAD3 in transfected fibroblasts after TGF-β (4 ng/mL) stimulation. Right: Bar plots showing relative fluorescence intensity of TGFBR1 and SMAD3. OD, optical density; *P 

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