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Western Blot analysis of extracts from various samples, using TGM2 Mouse Monoclonal Antibody.

BF8037 at 1/100 staining human prostate cancer by IHC-P.

产品:	TGM2 小鼠单克隆抗体
货号:	BF8037
描述:	Mouse monoclonal antibody to TGM2
应用:	WB IHC
反应:	Human, Mouse, Rat
预测:	Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量:	77kDa; 77kD(Calculated).
蛋白号:	P21980

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阻断肽(封闭肽)是特异性结合目标抗体和阻断抗体结合的多肽。这些多肽包含抗体识别的抗原表位。与阻断肽结合的抗体不再与靶蛋白上的表位结合。例如，在免疫印迹(WB)和免疫组化(IHC)中，通过比较被阻断抗体和未阻断抗体的染色，可以看到哪种染色是特异性的。

规格	价格	库存
50ul	RMB¥ 1250	现货
100ul	RMB¥ 2300	现货
200ul	RMB¥ 3000	现货

货期: 当天发货

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实验方案

产品描述

来源:

Mouse

应用:

WB 1:500-1:3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:

Human,Mouse,Rat

克隆:

Monoclonal [AFfirm8037(AFP21832)]

特异性:

TGM2 Antibody detects endogenous levels of total TGM2.

偶联:

Unconjugated.

纯化:

Affinity-chromatography.

保存:

Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

别名:

展开/折叠

ALPHA SUBUNIT; C polypeptide; EC 2.3.2.13; epididymis secretory protein Li 45; G alpha h; G[a]h; Gh CLASS G ALPHA h; GNAH; GNAH G PROTEIN; H POLYPEPTIDE; HEL-S-45; Protein glutamine gamma glutamyltransferase 2; Protein-glutamine gamma-glutamyltransferase 2; TG 2; TG(C); TG2; TGase C; TGase H; TGase-2; TgaseII; TGC; TGC GUANINE NUCLEOTIDE BINDING PROTEIN; TGM2; TGM2_HUMAN; Tissue transglutaminase; Transglutaminase 2; Transglutaminase 2 C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase-2; tTG; tTGas;

抗原和靶标

免疫原:

A synthesized peptide derived from human TGM2, corresponding to a region within N-terminal amino acids.

Uniprot:

P21980(TGM2_HUMAN) >>Visit HPA database.

基因/基因ID:

TGM2(7052)

描述:

TGM2 an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation.

序列:

P21980 TGM2_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVIIGPA

翻译修饰 - P21980 作为底物

P21980

Site	PTM Type	Enzyme	Source
A2	Acetylation		Uniprot
C10	S-Nitrosylation		Uniprot
C27	S-Nitrosylation		Uniprot
S56	Phosphorylation		Uniprot
S60	Phosphorylation		Uniprot
C98	S-Nitrosylation		Uniprot
S129	Phosphorylation		Uniprot
C143	S-Nitrosylation		Uniprot
Y159	Phosphorylation		Uniprot
K202	Acetylation		Uniprot
K205	Acetylation		Uniprot
S212	Phosphorylation		Uniprot
S215	Phosphorylation	P17612 (PRKACA)	Uniprot
S216	Phosphorylation	P17612 (PRKACA)	Uniprot
Y219	Phosphorylation		Uniprot
C230	S-Nitrosylation		Uniprot
Y245	Phosphorylation		Uniprot
S250	Phosphorylation		Uniprot
C269	S-Nitrosylation		Uniprot
C277	S-Nitrosylation		Uniprot
C285	S-Nitrosylation		Uniprot
Y315	Phosphorylation		Uniprot
C336	S-Nitrosylation		Uniprot
T368	Phosphorylation		Uniprot
Y369	Phosphorylation		Uniprot
C370	S-Nitrosylation		Uniprot
C371	S-Nitrosylation		Uniprot
S415	Phosphorylation		Uniprot
S419	Phosphorylation		Uniprot
S427	Phosphorylation		Uniprot
K464	Ubiquitination		Uniprot
C524	S-Nitrosylation		Uniprot
S538	Phosphorylation		Uniprot
S541	Phosphorylation		Uniprot
C545	S-Nitrosylation		Uniprot
C554	S-Nitrosylation		Uniprot
Y575	Phosphorylation		Uniprot
Y583	Phosphorylation		Uniprot
K590	Ubiquitination		Uniprot
S608	Phosphorylation		Uniprot
C620	S-Nitrosylation		Uniprot
K649	Ubiquitination		Uniprot
K672	Acetylation		Uniprot

翻译修饰 - P21980 作为激酶

P21980

Substrate	Site	Source
P68431 (HIST1H3J)	S11	Uniprot

研究背景

P21980_TGM2_HUMAN

功能:

Catalyzes the cross-linking of proteins, such as WDR54, and the conjugation of polyamines to proteins.

亚基结构:

Monomer.

蛋白家族:

Belongs to the transglutaminase superfamily. Transglutaminase family.

研究领域

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

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