FBXO31 Antibody - #DF15940

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产品: FBXO31 抗体
货号: DF15940
描述: Rabbit polyclonal antibody to FBXO31
应用: WB IF/ICC
反应: Human, Mouse, Rat
分子量: 61kD(Calculated).
蛋白号: Q5XUX0

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
FBXO31 Antibody detects endogenous levels of FBXO31.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

DKFZp434B027; DKFZp434J1815; F box only protein 31; F box protein 31; F-box only protein 31; FBX14; FBX31; FBX31_HUMAN; FBXO14; Fbxo31; FLJ22477; MGC15419; MGC9527; pp2386; Putative breast cancer tumor suppressor; SCF ubiquitin ligase specificity factor;

抗原和靶标

免疫原:

A synthesized peptide derived from human FBXO31.

Uniprot:

Q5XUX0(FBX31_HUMAN) >>Visit HPA database.

基因/基因ID:
FBXO31(79791)
表达:
Q5XUX0 FBX31_HUMAN:

Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.

序列:
MAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKLLHRYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVECMYGHKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIYTSQYDNCLTYRRIYLPPSRPDDLIKPGLFKGTYGSHGLEIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRNFNELSRIVLEVRERVRQEQQEGGHEAGEGRGRQGPRESQPSPAQPRAEAPSKGPDGTPGEDGGEPGDAVAAAEQPAQCGQGQPFVLPVGVSSRNEDYPRTCRMCFYGTGLIAGHGFTSPERTPGVFILFDEDRFGFVWLELKSFSLYSRVQATFRNADAPSPQAFDEMLKNIQSLTS

研究背景

功能:

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.

翻译修饰:

Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.

组织特异性:

Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.

亚基结构:

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

蛋白家族:

Belongs to the FBXO31 family.

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