产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Agtrap; Angiotensin II receptor associated protein; Angiotensin II type I receptor associated protein; AT1 receptor-associated protein; ATI receptor associated protein; ATRAP; ATRAP_HUMAN; MGC29646; OTTHUMP00000002269; OTTHUMP00000002270; OTTHUMP00000002271; Type 1 angiotensin II receptor associated protein; Type-1 angiotensin II receptor-associated protein;
抗原和靶标
A synthesized peptide derived from human AGTRAP.
- Q6RW13 ATRAP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELPAVNLKVILLGHWLLTTWGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGLLATIFLDIVHISIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVHTGFLGSSQDRSAYQTIDSAEAPADPFAVPEGRSQDARGY
研究背景
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Endoplasmic reticulum membrane>Multi-pass membrane protein. Golgi apparatus membrane>Multi-pass membrane protein. Cytoplasmic vesicle membrane>Multi-pass membrane protein.
Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
Interacts with RACK1, and with the C-terminal region of AGTR1.
限制条款
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