Trk B Antibody - #AF6461

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产品: Trk B 抗体
货号: AF6461
描述: Rabbit polyclonal antibody to Trk B
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Horse, Sheep, Rabbit, Chicken
蛋白号: Q16620
RRID: AB_2835281

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Trk B Antibody detects endogenous levels of total Trk B.
RRID:
AB_2835281
引用格式: Affinity Biosciences Cat# AF6461, RRID:AB_2835281.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AI848316; BDNF tropomyosine receptor kinase B; BDNF/NT 3 growth factors receptor; BDNF/NT-3 growth factors receptor; Brain derived neurotrophic factor receptor; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP95 TrkB; Neurotrophic receptor tyrosine kinase 2; Neurotrophic tyrosine kinase receptor type 2; Neurotrophin receptor tyrosine kinase type 2; NTRK 2; Ntrk2; NTRK2_HUMAN; Obesity, hyperphagia, and developmental delay, included; RATTRKB1; Tkrb; Trk B; Trk-B; TRKB; TrkB tyrosine kinase; TRKB1; Tropomyosin related kinase B; tyrosine kinase receptor B; Tyrosine receptor kinase B;

抗原和靶标

免疫原:

A synthesized peptide derived from human Trk B, corresponding to a region within C-terminal amino acids.

基因/基因ID:
NTRK2(4915)
描述:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation.

研究领域

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Ras signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Human Diseases > Substance dependence > Alcoholism.

· Organismal Systems > Nervous system > Neurotrophin signaling pathway.   (View pathway)

文献引用

1). SIRT3 alleviates mitochondrial dysfunction induced by recurrent low glucose and improves the supportive function of astrocytes to neurons. Free Radical Biology and Medicine, 2022 (PubMed: 36306990) [IF=7.1]
2). Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7, 8-dihydroxyflavone in female mice. Molecular Metabolism, 2021 (PubMed: 33352311) [IF=7.0]

Application: WB    Species: mouse    Sample: skeletal muscle and adipose

Figure 3.| Effect of 7,8-DHF treatment on gene and protein levels of ERα and ERβ in both skeletal muscle and adipose tissues.(E)–(F) Western blotting analysis of skeletal muscle and adipose tissues isolated from mice that have been treated with 7,8-DHF for 24 weeks. Protein levels of ERα and its two phosphorylated forms p-S118 and p-Y537, the phosphorylation of TrkB and two key energy metabolism-related proteins, AKT and UCP1 were measured. Representative immunoblots and quantification are shown (n = 3 per group. *p <0.05, **p < 0.01, N.S: not significant, LFD control vs. LFD+DHF10, Student’s t test; &p < 0.05, &&p < 0.01, N.S: not significant, HFD control vs. HFD+DHF5, Student’s t test).
3). Kaempferol-3-O-sophoroside (PCS-1) contributes to modulation of depressive-like behaviour in C57BL/6J mice by activating AMPK. British journal of pharmacology, 2023 (PubMed: 37949672) [IF=6.8]
4). Ketamine attenuates kidney damage and depression-like behaviors in mice with cisplatin-induced acute kidney injury. Translational psychiatry, 2024 (PubMed: 39521765) [IF=5.8]
5). TAT-Ngn2 Enhances Cognitive Function Recovery and Regulates Caspase-Dependent and Mitochondrial Apoptotic Pathways After Experimental Stroke. Frontiers in Cellular Neuroscience, 2018 (PubMed: 30618628) [IF=5.3]
6). Effects of Lifelong Exercise on Age-Related Body Composition, Oxidative Stress, Inflammatory Cytokines, and Skeletal Muscle Proteome in Rats. MECHANISMS OF AGEING AND DEVELOPMENT, 2020 (PubMed: 32422206) [IF=5.3]

Application: WB    Species: rat    Sample: gastrocnemius muscles

Fig. 6. |Expression of AKT/FOXO1 signaling pathway (A); mitochondrial function markers(B); BDNF signaling-related proteins (C); and representative confocal microscopy images of BDNF staining (green, magnification: ×40,scale Bar 50 μm) (D: a, 8 M–SED; b, 26 M–SED;c, 18 M–MICT; d, 8 M–MICT); and serum BDNF levels (E); and correlation analysis (F).
7). Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway. Molecular neurobiology, 2023 (PubMed: 38057644) [IF=4.6]
8). Aging Promotes Chronic Stress-Induced Depressive-Like Behavior by Activating NLRP1 Inflammasome-Driven Inflammatory Signaling in Mice. Inflammation, 2022 (PubMed: 35779196) [IF=4.5]
9). Esketamine improves cognitive function in sepsis-associated encephalopathy by inhibiting microglia-mediated neuroinflammation. European journal of pharmacology, 2024 (PubMed: 39312992) [IF=4.2]
10). MiR-132, miR-204 and BDNF-TrkB signaling pathway may be involved in spatial learning and memory impairment of the offspring rats caused by fluorine and aluminum exposure during the embryonic stage and into adulthood. Environmental Toxicology and Pharmacology, 2018 (PubMed: 30172012) [IF=4.2]
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