产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
E3 ubiquitin-protein ligase MARCH5; FLJ20445; MARCH-V; MARCH5; MARH5_HUMAN; Membrane-associated ring finger (C3HC4) 5; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; Mitochondrial ubiquitin ligase; MITOL; RING finger protein 153; RNF153;
抗原和靶标
A synthesized peptide derived from human MARCH5.
Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle.
- Q9NX47 MARH5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
研究背景
Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.
Autoubiquitinated leading to degradation (short half-life).
Mitochondrion outer membrane>Multi-pass membrane protein. Endoplasmic reticulum membrane>Multi-pass membrane protein.
Note: Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301).
Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle.
Monomer and homodimer. Interacts with MFN1, MFN2, DNM1L and FIS1.
The RING-CH-type zinc finger domain is required for E3 ligase activity.
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