产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
PRA1 domain family 1; PRA1 family protein 1; PRAF1; PRAF1_HUMAN; prenylated Rab acceptor 1; Prenylated Rab acceptor protein 1; Rab acceptor 1 (prenylated); RABAC1; YIP3;
抗原和靶标
A synthesized peptide derived from human RABAC1.
Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach.
- Q9UI14 PRAF1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAQKDQQKDAEAEGLSGTTLLPKLIPSGAGREWLERRRATIRPWSTFVDQQRFSRPRNLGELCQRLVRNVEYYQSNYVFVFLGLILYCVVTSPMLLVALAVFFGACYILYLRTLESKLVLFGREVSPAHQYALAGGISFPFFWLAGAGSAVFWVLGATLVVIGSHAAFHQIEAVDGEELQMEPV
研究背景
General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.
Cell membrane>Multi-pass membrane protein. Cytoplasm. Golgi apparatus. Cytoplasmic vesicle>Secretory vesicle>Synaptic vesicle.
Note: According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles.
Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach.
Homodimer. Interacts with VAMP2 (synaptobrevin-2), GDI1, and PCLO (By similarity). Interacts specifically with prenylated Rab proteins; strongly with RAB4B, RAB5A and RAB5C, and weakly with RAB4A, RAB6, RAB7A, RAB17 and RAB22. Interacts with NDRG1.
Belongs to the PRA1 family.
限制条款
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