产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
A6 related protein; A6-related protein; A6r; A6RP; hA6RP; MSTP011; Protein tyrosine kinase 9 like; Protein tyrosine kinase 9-like; PTK 9L; PTK9L; PTK9L protein tyrosine kinase 9 like; TWF 2; Twf2; TWF2_HUMAN; Twinfilin 1 like protein; Twinfilin 2; Twinfilin actin binding protein homolog 2; Twinfilin like protein; Twinfilin-1-like protein; Twinfilin-2; Twinfilin2;
抗原和靶标
A synthesized peptide derived from human TWF2.
- Q6IBS0 TWF2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGDDS
研究背景
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).
In vitro, phosphorylated by PRKCZ, CK2 and SRC.
Cytoplasm>Cytoskeleton. Cytoplasm>Perinuclear region. Cell projection>Stereocilium.
Note: Perinuclear and G-actin-rich cortical actin structure sublocalization.
Ubiquitously expressed (at protein level).
Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF1 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated. Interacts with MYO7A (By similarity).
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
限制条款
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