产品: NMDAR1 抗体
货号: AF6406
描述: Rabbit polyclonal antibody to NMDAR1
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Dog, Chicken, Xenopus
蛋白号: Q05586
RRID: AB_2835236

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
NMDAR1 Antibody detects endogenous levels of total NMDAR1.
RRID:
AB_2835236
引用格式: Affinity Biosciences Cat# AF6406, RRID:AB_2835236.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

GluN1; Glutamate [NMDA] receptor subunit zeta-1; Glutamate receptor ionotropic N methyl D aspartate 1; Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1; glutamate receptor ionotropic, NMDA 1; Grin1; MRD8; N methyl D aspartate receptor; N methyl D aspartate receptor channel subunit zeta 1; N methyl D aspartate receptor subunit NR1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA 1; NMDA R1; NMDA receptor 1; NMDA1; NMDAR; NMDZ1_HUMAN; NR1;

抗原和靶标

免疫原:

A synthesized peptide derived from human NMDAR1, corresponding to a region within C-terminal amino acids.

基因/基因ID:
描述:
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus.

研究领域

· Environmental Information Processing > Signal transduction > Ras signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Rap1 signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Calcium signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.

· Human Diseases > Neurodegenerative diseases > Amyotrophic lateral sclerosis (ALS).

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

· Human Diseases > Substance dependence > Cocaine addiction.

· Human Diseases > Substance dependence > Amphetamine addiction.

· Human Diseases > Substance dependence > Alcoholism.

· Organismal Systems > Environmental adaptation > Circadian entrainment.

· Organismal Systems > Nervous system > Long-term potentiation.

· Organismal Systems > Nervous system > Glutamatergic synapse.

文献引用

1). ICU patient-on-a-chip emulating orchestration of mast cells and cerebral organoids in neuroinflammation. Communications biology, 2024 (PubMed: 39639082) [IF=5.9]

2). STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons. CNS Neuroscience & Therapeutics, 2020 (PubMed: 32436359) [IF=4.8]

Application: WB    Species: mouse    Sample: hippocampus

FIGURE 5| STK24 is a potential binding partner of the NMDAR complex in the hippocampus of PTZ-kindled mice. A, STK24 interacts with the NMDAR complex, but not with the AMPAR complex. Hippocampal lysates from PTZkindled mice were immunoprecipitated with STK24 antibody and incubated with corresponding antibodies (IB: immunoblotting, IP: immunoprecipitation). B–F, Lysates from hippocampus of PTZkindled mice were immunoprecipitated with antibodies against NR1(B), NR2A(C), NR2B(D), GluR1(E), GluR2(F), and incubated with corresponding antibodies

3). Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements. Scientific Reports, 2021 (PubMed: 33446747) [IF=3.8]

Application: WB    Species: rat    Sample: liver tissues

Figure 5. Iron related indexes and neural development of ofspring rats afer iron supplement treatment. Western blot analysis for FTL and Tf in liver (a–c) and spleen (d–f). Morris water maze test for day 1 escape latency (g) and day 2 escape latency (h). Western blot analysis for FTL and Tf in brain (i–k) and hippocampus (l–n), and for SYN1, NMDAR, PSD-95 in hippocampus (o–r). Te quantifcation of western blotting was provided in supplementary material. FTL ferritin light chain, Tf transferrin, SYN1 synapsin 1, NMDAR N-methyl-D-aspartate receptor, PSD-95 postsynaptic density protein 95. Data of Western blot analysis (mean±SD) are expressed as the ratio of the relative contents between the value from IDA group and NG group and six iron treatment groups (n=3). Te relative contents of target proteins were quantifed using the ratio between the optical density (OD) of target protein and the amount of the housekeeping protein GAPDH. **p<0.01, compared with NG, #p<0.05, ##p<0.01, compared with IDAG. One-way ANOVA followed by Tukey multiple comparison test was used for comparison among 8 diferent groups.

4). PAG neuronal NMDARs activation mediated morphine-induced hyperalgesia by HMGB1-TLR4 dependent microglial inflammation. Journal of psychiatric research, 2023 (PubMed: 37352811) [IF=3.7]

5). Untargeted metabolomics revealed that quercetin improved adrenal gland metabolism disorders and modulated the HPA axis in perimenopausal depression model rats. The Journal of steroid biochemistry and molecular biology, 2025 (PubMed: 39914680) [IF=2.7]

6). Electroacupuncture induces analgesia by regulating spinal synaptic plasticity via the AMPA/NMDA receptor in a model of cervical spondylotic radiculopathy: secondary analysis of an experimental study in rats. Acupuncture in medicine : journal of the British Medical Acupuncture Society, 2025 (PubMed: 39895325) [IF=2.4]

7). Emotional and Cognitive Impairment Induced by Sleep Deprivation Due to Altered Synaptic Plasticity in the Rat Insula. , 2020

8). Effects of Prolonged High-Fat Diet Consumption Starting at Different Ages on Behavioral Parameters and Hippocampal Neuroplasticity in Male Mice. Journal of integrative neuroscience, 2023 (PubMed: 36722241)

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