RUNX1 / AML1 Antibody - #AF6379

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产品: RUNX1 / AML1 抗体
货号: AF6379
描述: Rabbit polyclonal antibody to RUNX1 / AML1
应用: WB IHC IF/ICC
文献验证: WB, IHC
反应: Human, Mouse, Rat
预测: Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
蛋白号: Q01196
RRID: AB_2835220

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
RUNX1 / AML1 Antibody detects endogenous levels of total RUNX1 / AML1.
RRID:
AB_2835220
引用格式: Affinity Biosciences Cat# AF6379, RRID:AB_2835220.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Acute myeloid leukemia 1; Acute myeloid leukemia 1 protein; alpha subunit core binding factor; AML 1; AML1; AML1 EVI 1; AML1 EVI 1 fusion protein; Aml1 oncogene; AMLCR 1; AMLCR1; CBF alpha 2; CBF-alpha-2; CBFA 2; CBFA2; Core binding factor alpha 2 subunit; Core binding factor runt domain alpha subunit 2; Core-binding factor subunit alpha-2; EVI 1; EVI1; HGNC; Oncogene AML 1; Oncogene AML-1; OTTHUMP00000108696; OTTHUMP00000108697; OTTHUMP00000108699; OTTHUMP00000108700; OTTHUMP00000108702; PEA2 alpha B; PEA2-alpha B; PEBP2 alpha B; PEBP2-alpha B; PEBP2A2; PEBP2aB; Polyomavirus enhancer binding protein 2 alpha B subunit; Polyomavirus enhancer-binding protein 2 alpha B subunit; Run1; Runt related transcription factor 1; Runt-related transcription factor 1; RUNX 1; Runx1; RUNX1_HUMAN; SL3 3 enhancer factor 1 alpha B subunit; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core binding factor alpha B subunit; SL3/AKV core-binding factor alpha B subunit;

抗原和靶标

免疫原:

A synthesized peptide derived from human RUNX1 / AML1, corresponding to a region within the internal amino acids.

基因/基因ID:
RUNX1(861)
描述:
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters.

研究领域

· Cellular Processes > Cellular community - eukaryotes > Tight junction.   (View pathway)

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

· Human Diseases > Cancers: Specific types > Chronic myeloid leukemia.   (View pathway)

· Human Diseases > Cancers: Specific types > Acute myeloid leukemia.   (View pathway)

· Organismal Systems > Immune system > Th17 cell differentiation.   (View pathway)

文献引用

1). Upregulation of Runt related transcription factor 1 (RUNX1) contributes to tendon–bone healing after anterior cruciate ligament reconstruction using bone mesenchymal stem cells. Journal of Orthopaedic Surgery and Research, 2022 (PubMed: 35562802) [IF=2.8]

Application: WB    Species: Rat    Sample: BMSCs

Fig. 1 Phenotype identification of BMSCs. A Primary BMSCs exhibited a long spindle shape (100× magnification). B BMSCs surface antigen identification by flow cytometry. C BMSCs infected with LV-NC or LV-RUNX1 by fluorescence microscopy (100× magnification). D The mRNA and protein expression of RUNX1 in BMSCs. ##p < 0.01

Application: IHC    Species: Rat    Sample: BMSCs

Fig. 4 RUNX1-upregulated BMSCs promotes osteogenesis after ACL reconstruction. A Micro-CT images of the knee joints. B BMD and BV/TV. C ALP-stained cells in tendon to bone interface (400× magnification). Black arrows indicated the ALP-positive cells. D, E The expression of OCN and OPN was assessed by immunohistochemistry (800× magnification). Black arrows indicated the OCN and OPN-positive cells in tendon to bone interface. #p < 0.05, ##p < 0.01; NS not significant

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