| 产品: | WRNIP1 抗体 |
| 货号: | DF14889 |
| 描述: | Rabbit polyclonal antibody to WRNIP1 |
| 应用: | WB ELISA(peptide) |
| 反应: | Human, Mouse, Rat |
| 分子量: | 72kD(Calculated). |
| 蛋白号: | Q96S55 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
ATPase WRNIP 1; ATPase WRNIP1; bA420G6.2; FLJ22526; Putative helicase RUVBL; RP11 420G6.2; Werner helicasae interacting protein 1; Werner helicasae interacting protein; Werner helicase interacting protein isoform 2; Werner helicase-interacting protein 1; WHIP; WRIP1_HUMAN; WRNIP 1; WRNIP; Wrnip1;
抗原和靶标
A synthesized peptide derived from human WRNIP1.
- Q96S55 WRIP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHPAGHAEPAAGSHRAGERAKGPSPPGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPTPSGARLIPDFPVARSSSPGRKGSGKRPAAAAAAGSASPRSWDEAEAQEEEEAVGDGDGDGDADADGEDDPGHWDADAAEAATAFGASGGGRPHPRALAAEEIRQMLQGKPLADTMRPDTLQDYFGQSKAVGQDTLLRSLLETNEIPSLILWGPPGCGKTTLAHIIASNSKKHSIRFVTLSATNAKTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQDTFLPHVECGTITLIGATTENPSFQVNAALLSRCRVIVLEKLPVEAMVTILMRAINSLGIHVLDSSRPTDPLSHSSNSSSEPAMFIEDKAVDTLAYLSDGDARAGLNGLQLAVLARLSSRKMFCKKSGQSYSPSRVLITENDVKEGLQRSHILYDRAGEEHYNCISALHKSMRGSDQNASLYWLARMLEGGEDPLYVARRLVRFASEDIGLADPSALTQAVAAYQGCHFIGMPECEVLLAQCVVYFARAPKSIEVYSAYNNVKACLRNHQGPLPPVPLHLRNAPTRLMKDLGYGKGYKYNPMYSEPVDQEYLPEELRGVDFFKQRRC
研究背景
Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.
Sumoylated with SUMO1 and SUMO2/3.
Nucleus. Cytoplasm.
Note: Colocalizes with WRN in granular structures in the nucleus.
Ubiquitously expressed.
Forms homooligomers, possibly octamers. Directly interacts with POLD1, POLD2 and POLD4. Interacts with the N-terminal domain of WRN (By similarity). Interacts (via UBZ4-type zinc finger) with monoubiquitin and polyubiquitin. Interacts with TRIM14 and PPP6C; these interactions positively regulate the RIG-I/DDX58 signaling pathway.
The UBZ4-type zinc finger binds ubiquitin.
Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
限制条款
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