产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
1300010A20Rik; AI035228; hPen; MGC30714; MGC50844; PEN; Penumbra; Proerythroblast new membrane; RGD1560915; Tetraspanin-33; TSN33; TSN33_HUMAN; Tspan-33; TSPAN33; Tspan33 tetraspanin 33;
抗原和靶标
A synthesized peptide derived from human TSPAN33.
- Q86UF1 TSN33_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MARRPRAPAASGEEFSFVSPLVKYLLFFFNMLFWVISMVMVAVGVYARLMKHAEAALACLAVDPAILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLTAVFLLQLAAGILGFVFSDKARGKVSEIINNAIVHYRDDLDLQNLIDFGQKKFSCCGGISYKDWSQNMYFNCSEDNPSRERCSVPYSCCLPTPDQAVINTMCGQGMQAFDYLEASKVIYTNGCIDKLVNWIHSNLFLLGGVALGLAIPQLVGILLSQILVNQIKDQIKLQLYNQQHRADPWY
研究背景
Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7.
Cell membrane>Multi-pass membrane protein. Cell junction>Adherens junction. Cytoplasm.
Note: Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction.
Predominantly expressed in erythroblasts.
Homodimer; disulfide-linked. Interacts (via extracellular domain) with ADAM10 (via extracellular domain). Interacts (via cytoplasmic domain) with PLEKHA7 (via WW domains); the interaction is dependent on PDZD11 being bound to PLEKHA7 and facilitates the docking of ADAM10 to zonula adherens.
Belongs to the tetraspanin (TM4SF) family.
限制条款
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