CCDC80 Antibody - #DF14680

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产品: CCDC80 抗体
货号: DF14680
描述: Rabbit polyclonal antibody to CCDC80
应用: IF/ICC
文献验证: IF/ICC
反应: Human, Mouse, Rat
分子量: 108kD(Calculated).
蛋白号: Q76M96

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产品描述

来源:
Rabbit
应用:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CCDC80 Antibody detects endogenous levels of CCDC80.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

2610001E17Rik; CCD50; CCD80_HUMAN; CCDC80; CL2; Coiled coil domain containing 80; Coiled coil domain containing protein 50; Coiled-coil domain-containing protein 80; Down regulated by oncogenes protein 1; Down-regulated by oncogenes protein 1; DRO1; MGC131805; MGC134851; Nuclear envelope protein okuribin; okuribin; OTTMUSP00000030743; Protein Ymer; SSG1; steroid sensitive gene 1; steroid sensitive protein 1; Up-regulated in BRS-3 deficient mouse homolog; URB;

抗原和靶标

免疫原:

A synthesized peptide derived from human CCDC80.

Uniprot:

Q76M96(CCD80_HUMAN) >>Visit HPA database.

基因/基因ID:
CCDC80(151887)
表达:
Q76M96 CCD80_HUMAN:

Expressed in dermal papilla and dermal fibroblasts (at protein level). Expressed in heart, thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts.

序列:
MTWRMGPRFTMLLAMWLVCGSEPHPHATIRGSHGGRKVPLVSPDSSRPARFLRHTGRSRGIERSTLEEPNLQPLQRRRSVPVLRLARPTEPPARSDINGAAVRPEQRPAARGSPREMIRDEGSSARSRMLRFPSGSSSPNILASFAGKNRVWVISAPHASEGYYRLMMSLLKDDVYCELAERHIQQIVLFHQAGEEGGKVRRITSEGQILEQPLDPSLIPKLMSFLKLEKGKFGMVLLKKTLQVEERYPYPVRLEAMYEVIDQGPIRRIEKIRQKGFVQKCKASGVEGQVVAEGNDGGGGAGRPSLGSEKKKEDPRRAQVPPTRESRVKVLRKLAATAPALPQPPSTPRATTLPPAPATTVTRSTSRAVTVAARPMTTTAFPTTQRPWTPSPSHRPPTTTEVITARRPSVSENLYPPSRKDQHRERPQTTRRPSKATSLESFTNAPPTTISEPSTRAAGPGRFRDNRMDRREHGHRDPNVVPGPPKPAKEKPPKKKAQDKILSNEYEEKYDLSRPTASQLEDELQVGNVPLKKAKESKKHEKLEKPEKEKKKKMKNENADKLLKSEKQMKKSEKKSKQEKEKSKKKKGGKTEQDGYQKPTNKHFTQSPKKSVADLLGSFEGKRRLLLITAPKAENNMYVQQRDEYLESFCKMATRKISVITIFGPVNNSTMKIDHFQLDNEKPMRVVDDEDLVDQRLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEVPITMKSVFDLIDTFQSRIKDMEKQKKEGIVCKEDKKQSLENFLSRFRWRRRLLVISAPNDEDWAYSQQLSALSGQACNFGLRHITILKLLGVGEEVGGVLELFPINGSSVVEREDVPAHLVKDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYDLIDSMQLRRQEMAIQQSLGMRCPEDEYAGYGYHSYHQGYQDGYQDDYRHHESYHHGYPY

研究背景

功能:

Promotes cell adhesion and matrix assembly.

翻译修饰:

Phosphorylated.

细胞定位:

Secreted>Extracellular space>Extracellular matrix.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in dermal papilla and dermal fibroblasts (at protein level). Expressed in heart, thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts.

亚基结构:

Binds to various extracellular matrix proteins.

蛋白家族:

Belongs to the CCDC80 family.

文献引用

1). Enhanced purification of uterine smooth muscle cells from adenomyosis using a novel dual-enzyme digestion method. New biotechnology, 2024 (PubMed: 39521046) [IF=4.5]

Application: IF/ICC    Species: human    Sample: P1 cells

Fig. 3. Tissue adhesion method generates progenitor cells that differentiate towards fibroblast-like cells. A. RNA velocity trajectory for all clusters shown by UMAP. B. Proportion of clusters in tissue adhesion and DM4 samples. C. Heatmap comparing highly expressed genes across all clusters. D. Feature plots demonstrating expression of fibroblast-related genes: FN1, COL1A2, COL3A1. E. Immunofluorescence images of CCDC80 and ACTA2 in P1 cells obtained from tissue adhesion and DM4. F. Immunofluorescence images of COL III and ACTA2 in P1 cells cultured continuously for 5 days. G. Statistical analysis of CCDC80/ACTA2 fluorescence expression ratio in P1 cells obtained from tissue adhesion and DM4 (n = 3, ns: non-significant, *P 

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