PROM2 Antibody - #DF14670

Fig. 1 Identification of ferroptosis-related genes induced by artesunate (ART) by RNA-seq (A) Volcano plot showed differentially expressed genes (DEGs) between control and ART-treated ES2 cells (|log2FC| > 1 and p value 

Fig. 7 Artesunate (ART) induced ferroptosis-mediated tumor inhibition by suppressing the HOXC11/PROM2/PI3K/AKT pathway in a SKOV3 xenograft mouse model (A) Scheme of the experimental design and timeline for the tumor model. SKOV3 cells (5 × 106 cells for each mouse) were inoculated into BALB/c-nude mice subcutaneously. Tumor-bearing mice were treated with vehicle (5% DMSO) or ART at 70 mg/kg daily for 25 days (n = 6 for each group). Body weights and tumor volumes were monitored every three days. B Images of xenograft nude mice and tumor mass. C Curve of tumor volume. D Curve of body weight. E Tumor weight. The superoxide dismutase (SOD) activity (F), glutathione (GSH) levels (G) and malondialdehyde (MDA) levels (H) were measured in the tumor tissue of nude mice. I IHC staining was performed to detect the expression of HOXC11, PROM2 and GPX4 in the tumor tissues of xenografted mice. J Western blot analysis of HOXC11, PROM2, GPX4, p-PI3K, PI3KCG, p-AKT and AKT in tumor tissue samples obtained from xenograft mice treated with vehicle or ART. GAPDH was used as a loading control. Data were analyzed as the mean ± SD of three independent experiments. *p