CD130/gp130 Antibody - #AF6291

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产品: CD130/gp130 抗体
货号: AF6291
描述: Rabbit polyclonal antibody to CD130/gp130
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: P40189
RRID: AB_2835141

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CD130/gp130 Antibody detects endogenous levels of total CD130/gp130.
RRID:
AB_2835141
引用格式: Affinity Biosciences Cat# AF6291, RRID:AB_2835141.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CD130; CD130 antigen; CDw130; gp130; GP130 RAPS; IL 6R beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6 ST; IL6RB_HUMAN; IL6ST; Interleukin 6 receptor subunit beta; Interleukin receptor beta chain; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; Membrane glycoprotein gp130; Oncostatin M receptor; Oncostatin M receptor alpha subunit; Oncostatin-M receptor subunit alpha;

抗原和靶标

免疫原:

A synthesized peptide derived from human CD130/gp130, corresponding to a region within C-terminal amino acids.

基因/基因ID:
IL6ST(3572)
描述:
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors.

研究领域

· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway.   (View pathway)

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Viral carcinogenesis.

· Organismal Systems > Immune system > Th17 cell differentiation.   (View pathway)

文献引用

1). CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway. iScience, 2023 (PubMed: 37860696) [IF=5.8]
2). Antinociceptive effects of IL-6R vs. glucocorticoid receptors during rat hind paw inflammatory pain. NEUROSCIENCE LETTERS, 2020 (PubMed: 32898615) [IF=2.5]

Application: WB    Species: rat    Sample: spinal cord

Fig. 4. |IL-6-induced signaling pathway test was assessed in the spinal cord by Western blotting, and the IL-6 and sIL-6R concentration levels in the serum and CSF were tested by ELISA. A–H: Levels of IL-6, IL-6Rα, gp130, JAK2, pJAK2, STAT3, and pSTAT3 proteins in the spinal cord following three consecutive days of i.th. injection of anti-IL-6R (20 μg/d), sgp130 (20 μg/d), and Dexamethasone (20 μg/d).

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