| 产品: | ITM2C 抗体 |
| 货号: | DF14177 |
| 描述: | Rabbit polyclonal antibody to ITM2C |
| 应用: | ELISA(peptide) |
| 反应: | Human, Mouse, Rat |
| 分子量: | 30kD; 30kD(Calculated). |
| 蛋白号: | Q9NQX7 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
BRI3; BRICD2C; BRICHOS domain containing 2C; Cerebral protein 14; CT-BRI3; E25; E25C; Integral membrane protein 2C; Integral membrane protein 3; Itm2c; ITM2C_HUMAN; ITM3; NPD018; Transmembrane protein BRI3;
抗原和靶标
A synthesized peptide derived from Human ITM2C.
High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.
- Q9NQX7 ITM2C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVKISFQPAVAGIKGDKADKASASAPAPASATEILLTPAREEQPPQHRSKRGGSVGGVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFRCGVLYEDSLSSQVRTQMELEEDVKIYLDENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVSDKEALGSFIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFENTFVVETLICGVV
研究背景
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembanaire cleavage by SPPL2B.
Lysosome membrane>Single-pass type II membrane protein. Cell membrane>Single-pass type II membrane protein.
High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.
Interacts with BACE1. Interacts with APP. Interacts with STMN2.
Belongs to the ITM2 family.
限制条款
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