| 产品: | STOM 抗体 |
| 货号: | DF13948 |
| 描述: | Rabbit polyclonal antibody to STOM |
| 应用: | ELISA(peptide) |
| 反应: | Human, Mouse, Rat |
| 分子量: | 32kD; 32kD(Calculated). |
| 蛋白号: | P27105 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
BND7; EPB7; EPB72; Erythrocyte band 7 integral membrane protein; Erythrocyte membrane protein band 7.2 (stomatin); Erythrocyte surface protein band 7.2; Protein 7.2b; STOM; STOM_HUMAN; Stomatin;
抗原和靶标
A synthesized peptide derived from Human STOM.
- P27105 STOM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAEKRHTRDSEAQRLPDSFKDSPSKGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHSHLG
研究背景
Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton. Cell membrane>Lipid-anchor>Cytoplasmic side. Membrane raft. Melanosome. Cytoplasmic vesicle.
Note: Localizes to juxtanuclear structure probably derived from the Golgi apparatus (PubMed:9243190). Colocalizes with cortical actin microfilaments at small plasma membrane protrusions (PubMed:9243190). Associates with alpha-granular lipid rafts (PubMed:12130500). Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles (PubMed:12130500). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).
Detected in erythrocytes (at protein level). Widely expressed.
Homodimer and higher order homooligomer. The homodimer is banana-shaped. Interacts with ASIC1, ASIC2 and ASIC3 (By similarity). Interacts with LANCL1. Interacts with SLC2A1 and SLC4A1. Identified in large complexes with SLC40A1, SLC14A1, SLC29A1 and AQP1. Interacts with STOML1; may redistribute STOM from the plasma membrane to late endosomes.
Belongs to the band 7/mec-2 family.
限制条款
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