Melatonin Receptor 1A Antibody - #DF13877

Fig. 7: Oxidative phosphorylation and ferroptosis processes are activated in oligodendrocytes and astrocytes. A The results of the Western Blot show that the protein expression levels of Slc25a4, Ndufa4, and Atp6v0c, which are related to mitochondrial oxidative phosphorylation, are significantly increased in astrocytes and oligodendrocytes under PD conditions. Additionally, in PD astrocytes, there is a significant decrease in the expression of the Mt1 protein. B The results of the ELISA kit show that the Ca2+ content in astrocytes of PD mice is significantly increased. At the same time, the iron ion content in the SN of mice is significantly elevated, while the GSH content, total SOD activity, and MDA content are significantly decreased, indicating the presence of high levels of ROS and the activation of ferroptosis processes in the SN of PD mice.