| 产品: | THEM4 抗体 |
| 货号: | DF13871 |
| 描述: | Rabbit polyclonal antibody to THEM4 |
| 应用: | ELISA(peptide) |
| 反应: | Human, Mouse, Rat |
| 分子量: | 27kD; 27kD(Calculated). |
| 蛋白号: | Q5T1C6 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Acyl CoA thioesterase THEM4; Acyl coenzyme A thioesterase THEM4; C terminal modulator protein; Carboxyl-terminal modulator protein; CTMP; FLJ27206; MGC29636; OTTHUMP00000015248; Them4; THEM4_HUMAN; Thioesterase superfamily member 4;
抗原和靶标
A synthesized peptide derived from Human THEM4.
Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation.
- Q5T1C6 THEM4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLRSCAARLRTLGALCLPPVGRRLPGSEPRPELRSFSSEEVILKDCSVPNPSWNKDLRLLFDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLYSEATSLFIKLNPAKSLT
研究背景
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to inhibits AKT1 phosphorylation and activity. According to enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.
Phosphorylated.
Cell membrane. Cell projection>Ruffle membrane. Cytoplasm. Mitochondrion. Mitochondrion inner membrane>Peripheral membrane protein. Mitochondrion intermembrane space.
Note: Released from the mitochondria into the cytosol in response to apoptotic stimuli.
Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation.
Homodimer and homotetramer. Interacts with AKT1 in the cytosol.
Belongs to the THEM4/THEM5 thioesterase family.
研究领域
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
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