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产品描述
来源:
Rabbit
应用:
IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
反应:
Human
克隆:
Polyclonal
特异性:
Interleukin 34 Antibody detects endogenous levels of total Interleukin 34.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:
展开/折叠
C16orf77; Chromosome 16 open reading frame 77; FPT025; IL 34; IL-34; Il34; IL34_HUMAN; Interleukin 34; Interleukin-34; Interleukin34; MGC34647;
抗原和靶标
文献引用
1). Interactions between MFAP5 + fibroblasts and tumor-infiltrating myeloid cells shape the malignant microenvironment of colorectal cancer. Journal of translational medicine, 2023
(PubMed: 37344903)
[IF=7.4]
Application: IHC Species: human Sample:
Fig. 6 MFAP5 + fibroblasts modulate the phenotype of C1QC + macrophages through the IL34/CSF1R signal pathway. A The hierarchy plots of CSF signaling pathway network indicate the regulation of MFAP5 + fibroblasts and FABP5 + fibroblasts on myeloid cells in normal or tumor sites. B Violin plot of IL34, CSF1, and CSF1R expression of tumor-specific fibroblasts and myeloid cells in distinct tissues (normal or tumor). C Heatmap shows dominant senders, receivers, mediators and influencers in CSF signals of tumor inferred by network centrality score. D Bar plot shows the contribution of all L-R pairs in CSF pathway within the normal tissue. E Spatial images localize the expression of IL34 and CSF1R which suggest that the co-localization of IL34 and CSF1R in CRC slices. F Heat map of M1/M2 phenotype scores of three identified tumor-associated macrophage subtypes. G Immunohistochemical double-staining of MFAP5/CD163 and IL-34/CSF1R using continuous slides of CRC tissues (×20, 50 μm)
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