产品: VDAC3 抗体
货号: DF13768
描述: Rabbit polyclonal antibody to VDAC3
应用: WB IHC
反应: Human, Mouse, Rat
分子量: 30kD; 31kD(Calculated).
蛋白号: Q9Y277

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 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
VDAC3 Antibody detects endogenous levels of total VDAC3.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

hVDAC3; mVDAC3; Outer mitochondrial membrane protein porin 3; voltage dependent anion channel 3;

抗原和靶标

免疫原:

A synthesized peptide derived from Human VDAC3.

Uniprot:
基因/基因ID:
表达:
Q9Y277 VDAC3_HUMAN:

Widely expressed. Highest in testis.

序列:
MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA

翻译修饰 - Q9Y277 作为底物

Site PTM Type Enzyme
Ubiquitination
C2 Acetylation
T4 Phosphorylation
T6 Phosphorylation
Y7 Phosphorylation
K12 Acetylation
K12 Ubiquitination
K15 Acetylation
K15 Ubiquitination
K20 Acetylation
K20 Ubiquitination
Y22 Phosphorylation
K28 Acetylation
K28 Ubiquitination
C36 S-Nitrosylation
S44 Phosphorylation
Y48 Phosphorylation
T49 Phosphorylation
K53 Ubiquitination
K61 Acetylation
K61 Ubiquitination
K63 Acetylation
K63 Ubiquitination
C65 S-Nitrosylation
Y67 Phosphorylation
T70 Phosphorylation
K90 Acetylation
K90 Ubiquitination
K96 Acetylation
T107 Phosphorylation
K109 Acetylation
K109 Ubiquitination
K110 Acetylation
K110 Ubiquitination
K113 Acetylation
K115 Acetylation
K119 Acetylation
K163 Acetylation
K163 Ubiquitination
Y173 Phosphorylation
K174 Acetylation
Y195 Phosphorylation
K197 Ubiquitination
K224 Acetylation
Y247 Phosphorylation
T250 Phosphorylation
S260 Phosphorylation
K266 Acetylation
K266 Ubiquitination
K274 Ubiquitination

研究背景

功能:

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.

翻译修饰:

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

细胞定位:

Mitochondrion outer membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Widely expressed. Highest in testis.

蛋白家族:

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.

Belongs to the eukaryotic mitochondrial porin family.

研究领域

· Cellular Processes > Cell growth and death > Ferroptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Environmental Information Processing > Signal transduction > Calcium signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Human Diseases > Neurodegenerative diseases > Parkinson's disease.

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

· Human Diseases > Infectious diseases: Viral > Hepatitis B.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Human Diseases > Cancers: Overview > Viral carcinogenesis.

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Digestive system > Cholesterol metabolism.

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