AFfirm™ p53 Mouse monoclonal Antibody - #BF8013

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产品: p53 小鼠 单克隆 抗体
货号: BF8013
描述: Mouse monoclonal antibody to p53
应用: WB IF/ICC
文献验证: WB
反应: Human, Mouse
蛋白号: P04637

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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IF/ICC Protocol

产品描述

来源:
Mouse
应用:
WB 1:500-1:3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Monoclonal [AFfirm8013(AFB19419)]
特异性:
p53 Antibody detects endogenous levels of total p53.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Antigen NY-CO-13; BCC7; Cellular tumor antigen p53; FLJ92943; LFS1; Mutant tumor protein 53; p53; p53 tumor suppressor; P53_HUMAN; Phosphoprotein p53; Tp53; Transformation related protein 53; TRP53; Tumor protein 53; Tumor protein p53; Tumor suppressor p53;

抗原和靶标

免疫原:

A synthesized peptide derived from human p53.

基因/基因ID:
TP53(7157)

研究领域

· Cellular Processes > Cell growth and death > Cell cycle.   (View pathway)

· Cellular Processes > Cell growth and death > p53 signaling pathway.   (View pathway)

· Cellular Processes > Cell growth and death > Apoptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Ferroptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Wnt signaling pathway.   (View pathway)

· Human Diseases > Drug resistance: Antineoplastic > Endocrine resistance.

· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.

· Human Diseases > Neurodegenerative diseases > Amyotrophic lateral sclerosis (ALS).

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

· Human Diseases > Infectious diseases: Viral > Hepatitis C.

· Human Diseases > Infectious diseases: Viral > Hepatitis B.

· Human Diseases > Infectious diseases: Viral > Measles.

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

· Human Diseases > Cancers: Overview > Viral carcinogenesis.

· Human Diseases > Cancers: Overview > Proteoglycans in cancer.

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

· Human Diseases > Cancers: Specific types > Colorectal cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Pancreatic cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Endometrial cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Glioma.   (View pathway)

· Human Diseases > Cancers: Specific types > Prostate cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Thyroid cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Basal cell carcinoma.   (View pathway)

· Human Diseases > Cancers: Specific types > Melanoma.   (View pathway)

· Human Diseases > Cancers: Specific types > Bladder cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Chronic myeloid leukemia.   (View pathway)

· Human Diseases > Cancers: Specific types > Small cell lung cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Non-small cell lung cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Breast cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma.   (View pathway)

· Human Diseases > Cancers: Specific types > Gastric cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Central carbon metabolism in cancer.   (View pathway)

· Organismal Systems > Aging > Longevity regulating pathway.   (View pathway)

· Organismal Systems > Nervous system > Neurotrophin signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway.   (View pathway)

文献引用

1). Fluorinated Titanium Oxide (TiO2- xFx) Nanospindles as Ultrasound-Triggered Pyroptosis Inducers to Boost Sonodynamic Immunotherapy. ACS nano, 2024 (PubMed: 39010657) [IF=15.8]
2). The brain-protective mechanism of fecal microbiota transplantation from young donor mice in the natural aging process via exosome, gut microbiota, and metabolomics analyses. Pharmacological research, 2024 (PubMed: 39053865) [IF=9.1]
3). Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors. Cell Death & Disease, 2022 (PubMed: 36435804) [IF=8.1]
4). Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice. Aging cell, 2025 (PubMed: 39660787) [IF=8.0]

Application: WB    Species: Mouse    Sample:

FIGURE 2 Effects of Tert overexpression on lifespan and antioxidant capacity in mice. (a) Kaplan–Meier survival curve showing prolonged lifespan of G1–G5 TertKI mice compared to WT and EIIa-Cre mice. (b–f) Individual survival curves for each generation of TertKI mice (G1–G5) compared to WT and EIIa-Cre mice. (g) Kaplan–Meier survival curve separated by gender, showing comparable lifespan of female (n = 47) and male (n = 51) TertKI mice. Statistical differences are represented on the graph, with p 
5). The Role of Sensory Nerves in Dental Pulp Homeostasis: Histological Changes and Cellular Consequences after Sensory Denervation. International journal of molecular sciences, 2024 (PubMed: 38256202) [IF=5.6]
6). Research on the anti-aging mechanisms of Panax ginseng extract in mice: a gut microbiome and metabolomics approach. Frontiers in pharmacology, 2024 (PubMed: 38966558) [IF=5.6]
7). Study on the in vitro changes of human bone marrow‑related mesenchymal stem cells. International journal of molecular medicine, 2025 (PubMed: 39611467) [IF=5.4]
8). Glutathione-protected Au22 Nanoclusters Ameliorates Hypoxic-Ischemic Brain Damage in Neonatal Rats via Sirt3/SOD2 Signaling Pathway. Molecular neurobiology, 2025 (PubMed: 40119249) [IF=4.6]
9). Rapamycin attenuated podocyte apoptosis via upregulation of nestin in Ang II-induced podocyte injury. Molecular Biology Reports, 2022 (PubMed: 35149934) [IF=2.6]

Application: WB    Species: Mice    Sample: kidney tissues

Fig. 1 Rapamycin attenuated podocyte injury in Ang II-infused mice. a As indicated, Immunohistochemical staining for nephrin in kidney tissue from each group. Magnification, × 400. b Representative images of WT-1 immunofluorescent staining in kidney tissues from the above group. Magnification, × 400. c TUNEL staining (Red) in kidney sections after the indicated treatment. The sections were counterstained with DAPI (Blue). Magnification, × 400. d Western blotting analysis of nephrin, Bax and p53 expression in the kidney. The levels of GAPDH were used as standard loading controls. The data are presented as mean ± SEM. #P < 0.05 vs. control group, *P < 0.05 vs. Ang II group. (Color figure online)
10). ɑ-Solanine Affects the Apoptosis and Angiogenesis of M2-Like TAMs Cells by Regulating the PI3K/AKT/mTOR Signaling Pathway Under Hypoxia. Natural Product Communications, 2023 [IF=1.5]

Application: WB    Species: Human    Sample:

Figure 2. α-Solanine regulated angiogenic, proliferation, and apoptosis-related factors under hypoxic conditions. (A) Flow plots of apoptosis in each group. (B-J) Line plots of relative expressions of various target bands. *P 
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