(2)
(3)
产品描述
来源:
Mouse
应用:
IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
反应:
Human
克隆:
Monoclonal [AFfirm8008]
特异性:
SIGLEC15 Mouse Monoclonal Antibody detects endogenous levels of total SIGLEC15.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:
展开/折叠
CD33 antigen-like 3;CD33 molecule-like 3;CD33L3;HsT1361;Sialic acid-binding Ig-like lectin 15;SIG15_HUMAN;Siglec-15;SIGLEC15;
抗原和靶标
文献引用
1). Siglec-15 on macrophages suppress the immune microenvironment in patients with PD-L1 negative non-metastasis lung adenocarcinoma. Cancer gene therapy, 2024
(PubMed: 38072971)
[IF=4.8]
Application: IF/ICC Species: Mouse Sample: NSCLC tissue
Fig. 1: Different expression patterns of Siglec-15 and PD-L1 in LUAD. A Representative images of NSCLC tissue sections with Siglec-15 expression Pattern 1 (TC−Mφ−), Pattern 2 (TC−Mφ+), Pattern 3 (TC+Mφ+), and Pattern 4 (TC+Mφ−). Scale bar, 50 μm. B Representative images of NSCLC tissue sections with PD-L1 expression Pattern 1 (TC−NTC−), Pattern 2 (TC−NTC+), Pattern 3 (TC+NTC+), and Pattern 4 (TC+NTC-). Scale bar, 50 μm. C, D LUAD samples were divided into four groups according to their Siglec-15 or PD-L1 expression patterns. E Chi-Square test showed the relationship between Siglec-15 and PD-L1. F, G Comparison of DFS between patients with Siglec-15 or PD-L1 positivity and negativity.
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