Synaptotagmin 1/2 Antibody - #AF6223

Figure 10.| Sal promotes increases in dendritic spine density and synaptic-associated protein expression via upregulating the FGF2-mediated cAMP/PKA/CREB signaling pathway.(E–H) Representative western blot bands of PSD95, synapsin I and synaptotagmin in each group. (I) QPCR data for PSD95. (J) Transmission electron microscopy showed the synaptic structures (the scale bar is 1 μm). Values are expressed as the mean ± SD. #p < 0.05, ##p < 0.01 vs. sham; *p < 0.05, **p < 0.01 vs. MCAO/R.

Figure 6. Trelagliptin improved synaptic plasticity in the cerebral cortex of DM rats. (A) Western blot analysis of PSD95 (postsynaptic density protein 95), an essential postsynaptic scaffold protein that decreased in the DM group. (B) Western blot analysis of SYT1 (synaptotagmin 1), the primary regulator of synaptic transmission that functions as an integrin in the synaptic vesicular membrane; its expression decreased in DM rats (*P < 0.05, ***P < 0.001, and ****P < 0.0001).

Figure 2. EA reduced abnormal remodeling of dendritic spines/synapses, whereas BzATP had the opposite effects. (a) and (b) Representative Western blots and quantification data of the expression of Synaptotagmin 1/GAPDH. (n ¼ 3). (c) Dendritic spines. Scale bars, 10 lm. (d) Number of spines per 10 lm. (n ¼ 3). (e) The ultrastructure of synapses in the spinal dorsal horn from rats in each group (0.2 lm, 30,000 ). (f) Number of synapses per 30000x field. (n ¼ 4). (g) Width of synaptic space (nm). (n ¼ 4). (h) Vesicle density (vesicles/ mm2 ). (n ¼ 4). Columns represent the mean  SD. #p < 0.05 and ##p < 0.01 vs. the S group; $p < 0.05 and $$p < 0.01 vs. the M group; &&p < 0.01 vs. the MþEA group.