ADRB2 Antibody - #AF6117

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产品: ADRB2 抗体
货号: AF6117
描述: Rabbit polyclonal antibody to ADRB2
应用: WB IHC IF/ICC
文献验证: WB, IHC, IF/ICC
反应: Human, Mouse
预测: Bovine, Rabbit, Dog
蛋白号: P07550
RRID: AB_2835001

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
ADRB2 Antibody detects endogenous levels of total ADRB2.
RRID:
AB_2835001
引用格式: Affinity Biosciences Cat# AF6117, RRID:AB_2835001.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ADRB2; ADRB2_HUMAN; ADRB2R; ADRBR; Adrenergic beta 2 receptor surface; Adrenoceptor beta 2 surface; B2AR; BAR; beta 2 adrenoceptor; Beta 2 adrenoreceptor; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; BETA2AR; Catecholamine receptor; OTTHUMP00000160386;

抗原和靶标

免疫原:

A synthesized peptide derived from human ADRB2, corresponding to a region within C-terminal amino acids.

基因/基因ID:
ADRB2(154)
描述:
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2.

研究领域

· Environmental Information Processing > Signal transduction > Calcium signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Endocrine system > Regulation of lipolysis in adipocytes.

· Organismal Systems > Endocrine system > Renin secretion.

· Organismal Systems > Digestive system > Salivary secretion.

文献引用

1). Mammalian Eps15 homology domain 1 potentiates angiogenesis of non-small cell lung cancer by regulating β2AR signaling. Journal of Experimental & Clinical Cancer Research, 2019 (PubMed: 31023336) [IF=11.3]

Application: WB    Species: mouse    Sample: xenograft tumo

Fig. 6| Targeting of VEGFA represses EHD1-induced tumor growth and angiogenesis in vivo. a-b The expression of EHD1, β2AR and VEGFA in freshly frozen xenograft tumor tissue was analyzed by Western blot.

Application: IHC    Species: human    Sample: HCC

Figure S9. |Correlation of EHD1 with β2AR, VEGFA and CD31 expression and angiogenesis in HCC tissues. a Representative IHC images of NSCLC samples with low and high expression of the indicated proteins. Scale bar, 50 μm and 100 μm.
2). Quercetin inhibits chronic stress-mediated progression of triple-negative breast cancer by blocking β2-AR/ERK1/2 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2024 (PubMed: 38901200) [IF=6.9]
3). Baicalin reduces chronic stress-induced breast cancer metastasis via directly targeting β2-adrenergic receptor. Journal of pharmaceutical analysis, 2024 (PubMed: 39139999) [IF=6.1]
4). ADRB2 serves as a novel biomarker and attenuates alcoholic hepatitis via the SIRT1/PGC-1α/PPARα pathway: integration of WGCNA, machine learning and experimental validation. Frontiers in pharmacology, 2024 (PubMed: 39640486) [IF=5.6]

Application: IHC    Species: human    Sample:

Figure 4. Identification and verification of the diagnostic biomarkers of alcoholic hepatitis. (A) From the chosen modules, diagnostic markers were screened using the Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression approach. (B) Diagnostic nomogram. (C) Receiver operating characteristic curves to assess the diagnostic ability. (D) Box plots for the differential expression analysis in the metadata. (E) Box plots for the ADRB2 differential expression analysis in the testing data sets. (F) Immunohistochemical analysis of ADRB2 expression in normal groups and patients with alcoholic hepatitis.

Application: WB    Species: Mouse    Sample: liver tissues

Figure 8. Low expression of ADRB2, SIRT1, PGC-1α, and PPARα in ethanol-induced alcoholic hepatitis. (A) Western blot analysis of ADRB2 in NIAAA mouse liver tissues. (B) Statistical results of NIAAA mouse liver western blot analysis. (C) Immunofluorescence of ADRB2 and SIRT1 in NIAAA mouse liver tissue. (D) Western blot analysis of ADRB2, PPARα, PGC-1α, and SIRT1 in ALD mouse liver tissues. (E) Statistical results of ALD mouse liver western blot analysis. (F) Immunofluorescence of ADRB2 and SIRT1 in ALD mouse liver tissue. * Represents p < 0.05 and ** represents p < 0.01, compared with the control group.

Application: IF/ICC    Species: Mouse    Sample: liver tissues

Figure 8. Low expression of ADRB2, SIRT1, PGC-1α, and PPARα in ethanol-induced alcoholic hepatitis. (A) Western blot analysis of ADRB2 in NIAAA mouse liver tissues. (B) Statistical results of NIAAA mouse liver western blot analysis. (C) Immunofluorescence of ADRB2 and SIRT1 in NIAAA mouse liver tissue. (D) Western blot analysis of ADRB2, PPARα, PGC-1α, and SIRT1 in ALD mouse liver tissues. (E) Statistical results of ALD mouse liver western blot analysis. (F) Immunofluorescence of ADRB2 and SIRT1 in ALD mouse liver tissue. * Represents p < 0.05 and ** represents p < 0.01, compared with the control group.
5). -bambuterol and its enantiomers: Potential improvement of (R)-bambuterol in mice with colitis. International Immunopharmacology, 2022 (PubMed: 34974400) [IF=4.8]

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