Acetyl-FOXO3A (Lys271) Antibody - #AF3771

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产品: 乙酰化FOXO3A (Lys271) 抗体
货号: AF3771
描述: Rabbit polyclonal antibody to Acetyl-FOXO3A (Lys271)
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
蛋白号: O43524
RRID: AB_2847085

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   规格 价格 库存
 100ul RMB¥ 2500 现货
 200ul RMB¥ 3500 现货

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WB Handbook
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IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Acetyl-FOXO3A (Lys271) Antibody detects endogenous levels of FOXO3A only when acetylated at Lys271.
RRID:
AB_2847085
引用格式: Affinity Biosciences Cat# AF3771, RRID:AB_2847085.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AF6q21; AF6q21 protein; DKFZp781A0677; FKHR2; FKHRL 1; FKHRL1; FKHRL1P2; Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1; Forkhead box O3; Forkhead box O3A; Forkhead box protein O3; Forkhead box protein O3A; Forkhead Drosophila homolog of in rhabdomyosarcoma like 1; Forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma like 1; Forkhead in rhabdomyosarcoma-like 1; FOX O3A; FOXO2; foxo3; FOXO3_HUMAN; FOXO3A; MGC12739; MGC31925;

抗原和靶标

免疫原:

A synthesized peptide derived from human FOXO3A around the acetylation site of Lys271.

基因/基因ID:
FOXO3(2309)

研究领域

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Environmental Information Processing > Signal transduction > FoxO signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > AMPK signaling pathway.   (View pathway)

· Human Diseases > Drug resistance: Antineoplastic > EGFR tyrosine kinase inhibitor resistance.

· Human Diseases > Cancers: Specific types > Endometrial cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Non-small cell lung cancer.   (View pathway)

· Organismal Systems > Immune system > Chemokine signaling pathway.   (View pathway)

· Organismal Systems > Aging > Longevity regulating pathway.   (View pathway)

· Organismal Systems > Aging > Longevity regulating pathway - multiple species.   (View pathway)

· Organismal Systems > Nervous system > Neurotrophin signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Prolactin signaling pathway.   (View pathway)

文献引用

1). NADPH Oxidase Mediates Oxidative Stress and Ventricular Remodeling through SIRT3/FOXO3a Pathway in Diabetic Mice. Antioxidants (Basel, Switzerland), 2022 (PubMed: 36139819) [IF=7.0]

Application: WB    Species: Mouse    Sample:

Figure 4. Apocynin regulates SIRT3/FOXO3a signaling pathway in diabetic cardiomyopathy. (A) Protein level of SIRT3 detected by Western blot analysis. (B) Quantification of SIRT3 in (A). (C) Expression of FOXO3a in ventricular tissues. (D) Quantification of FOXO3a in (C). (E) Representative confocal microscopy images of immunofluorescence stained for Ac-FOXO3a and DAPI. (F) Ac-FOXO3a fluorescence intensity quantification. Scale bar, 20 μm. (G) Expression of Ac-MnSOD in ventricular tissues among 3 groups. (H) Quantification of Ac-MnSOD in (G). Data are mean ± SD; n = 5 mice per group; * p < 0.05, ** p < 0.01, *** p < 0.001.
2). Theaflavin alleviates cisplatin-induced nephrotoxicity: Targeting SIRT1/p53/FOXO3a/Nrf2 signaling and the NF-kB inflammatory cascade. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2025 (PubMed: 39978533) [IF=3.9]
3). Urolithin A protects human dermal fibroblasts from UVA-induced photoaging through NRF2 activation and mitophagy. Journal of photochemistry and photobiology. B, Biology, 2022 (PubMed: 35567884) [IF=3.9]
4). Alleviation of Copper-Induced Hepatotoxicity by Bergenin: Diminution of Oxidative Stress, Inflammation, and Apoptosis via Targeting SIRT1/FOXO3a/NF-κB Axes and p38 MAPK Signaling. Biological trace element research, 2024 (PubMed: 39347884) [IF=3.4]

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