ATP1A1 Antibody - #AF6109

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产品: ATP1A1 抗体
货号: AF6109
描述: Rabbit polyclonal antibody to ATP1A1
应用: WB IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse, Rat
蛋白号: P05023
RRID: AB_2834996

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 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
ATP1A1 Antibody detects endogenous levels of total ATP1A1.
RRID:
AB_2834996
引用格式: Affinity Biosciences Cat# AF6109, RRID:AB_2834996.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

A1A1; AT1A1; AT1A1_HUMAN; ATP1A1; Atpa-1; ATPase Na+/K+ transporting alpha 1 polypeptide; ATPase Na+/K+ transporting subunit alpha 1; BC010319; EC 3.6.3.9; MGC3285; MGC38419; MGC51750; Na K ATPase alpha A catalytic polypeptide; Na K ATPase catalytic subunit alpha A protein; Na(+)/K(+) ATPase 1; Na(+)/K(+) ATPase alpha-1 subunit; Na+; K+ ATPase alpha subunit; Na+/K+ ATPase alpha 1 subunit; Na+/K+ ATPase 1; Na;K ATPase alpha 1 subunit; Nkaa1b; Sodium potassium ATPase alpha 1 polypeptide; Sodium pump 1; Sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; Sodium/potassium-transporting ATPase subunit alpha-1;

抗原和靶标

免疫原:

A synthesized peptide derived from human ATP1A1, corresponding to a region within N-terminal amino acids.

基因/基因ID:
ATP1A1(476)
描述:
ATP1A1 the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients.

研究领域

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Organismal Systems > Circulatory system > Cardiac muscle contraction.   (View pathway)

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Endocrine system > Insulin secretion.   (View pathway)

· Organismal Systems > Endocrine system > Thyroid hormone synthesis.

· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.

· Organismal Systems > Excretory system > Aldosterone-regulated sodium reabsorption.

· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.

· Organismal Systems > Excretory system > Proximal tubule bicarbonate reclamation.

· Organismal Systems > Digestive system > Salivary secretion.

· Organismal Systems > Digestive system > Gastric acid secretion.

· Organismal Systems > Digestive system > Pancreatic secretion.

· Organismal Systems > Digestive system > Carbohydrate digestion and absorption.

· Organismal Systems > Digestive system > Protein digestion and absorption.

· Organismal Systems > Digestive system > Mineral absorption.

文献引用

1). Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 (PubMed: 37862975) [IF=6.9]
2). Aldosterone down-regulates the slowly activated delayed rectifier potassium current in adult guinea pig cardiomyocytes. British Journal of Pharmacology, 2015 (PubMed: 25857626) [IF=6.8]

Application: WB    Species:    Sample:

3). Real-Ambient Particulate Matter Exposure-Induced Cardiotoxicity in C57/B6 Mice. Frontiers in Pharmacology, 2020 (PubMed: 32296328) [IF=5.6]

Application: WB    Species: Mice    Sample: heart tissues

Figure 5 Western blotting results. For 6 weeks, 6–8 weeks C57/B6 mice, with or without Nrf2 knockout, were exposed to either filtered air or air containing particulate matter (PM), and then the hearts were collected, snap-frozen in liquid nitrogen, extracted, and subjected to western blotting for p-SMAD2, SMAD2, p-p38MAPK, p38MAPK, p-TAK1, TAK1, ATP1a1, Grb2, p-JAK1, JAK1, p-STAT3, STAT3, and GAPDH. An additional group of WTC and WTE heart samples was processed with nuclear and cytoplasmic extraction kit (Epizyme, Shanghai, China) and probed for Nrf2 and GAPDH. N = 3 per group from three independent experiments. *Statistically different between the two groups (P < 0.05). **Statistically different between the two groups (P < 0.01).
4). Esculin ameliorates obesity-induced insulin resistance by improving adipose tissue remodeling and activating the IRS1/PI3K/AKT/GLUT4 pathway. Journal of ethnopharmacology, 2024 (PubMed: 37778516) [IF=4.8]
5). Comparison of the effects of green and black tea extracts on Na+ /K+ -ATPase activity in intestine of type 1 and type 2 diabetic mice. MOLECULAR NUTRITION & FOOD RESEARCH, 2019 (PubMed: 31197949) [IF=4.5]

Application: WB    Species: mouse    Sample: intestine

Figure 3.| Effect of green and black tea extracts on Na+/K+-ATPase in intestine. A) Activity of Na+/K+-ATPase in the intestine in type 1 diabetic mice model. B) Activity of Na+/K+-ATPase in the intestine in type 2 diabetic mice model. C) Protein expression of Na+/K+-ATPase in the intestine in type 1 diabetic mice model.
6). QiShenYiQi pills, a Chinese patent medicine, increase bioavailability of atorvastatin by inhibiting Mrp2 expression in rats. PHARMACEUTICAL BIOLOGY, 2022 (PubMed: 35001796) [IF=3.9]

Application: WB    Species: Rat    Sample: ileum

Figure 6. Protein expression of P-glycoprotein in jejunum and Mrp2 in ileum after oral or intravenous administration of ATV without or with QSYQ. (A) and (B) Protein expression of P-glycoprotein in jejunum; (C) and (D) Protein expression of Mrp2 in ileum. Data are shown as mean ± SD (n = 3). *p < 0.05 compared to without QSYQ.
7). Alkaliptosis induction counteracts paclitaxel-resistant ovarian cancer cells via ATP6V0D1-mediated ABCB1 inhibition. Molecular carcinogenesis, 2024 (PubMed: 38751020) [IF=3.0]
8). Endogenous acetylcholine increases alveolar epithelial fluid transport via activation of alveolar epithelial Na,K-ATPase in mice. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2015 (PubMed: 26134533) [IF=1.9]

Application: IF/ICC    Species: human    Sample: A549 cells

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