Phospho-Parkin (Ser65) Antibody - #AF3500

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产品: 磷酸化 Parkin (Ser65) 抗体
货号: AF3500
描述: Rabbit polyclonal antibody to Phospho-Parkin (Ser65)
应用: WB IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
蛋白号: O60260
RRID: AB_2846814

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   规格 价格 库存
 100ul RMB¥ 2800 现货
 200ul RMB¥ 3800 现货

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IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IF/ICC 1:100-1:500, WB 1:500-2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Phospho-Parkin (Ser65) Antibody detects endogenous levels of Parkin only when phosphorylated at Ser65.
RRID:
AB_2846814
引用格式: Affinity Biosciences Cat# AF3500, RRID:AB_2846814.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AR JP; E3 ubiquitin ligase; E3 ubiquitin protein ligase parkin; E3 ubiquitin-protein ligase parkin; FRA6E; LPRS 2; LPRS2; PARK 2; Park2; Parkin 2; Parkinson disease (autosomal recessive juvenile) 2; Parkinson disease (autosomal recessive, juvenile) 2, parkin; Parkinson disease protein 2; Parkinson juvenile disease protein 2; Parkinson protein 2 E3 ubiquitin protein ligase; Parkinson protein 2, E3 ubiquitin protein ligase (parkin); PDJ; PRKN 2; PRKN; PRKN2; PRKN2_HUMAN; Ubiquitin E3 ligase PRKN;

抗原和靶标

免疫原:

A synthesized peptide derived from human Parkin around the phosphorylation site of Ser65.

基因/基因ID:
PRKN(5071)

研究领域

· Genetic Information Processing > Folding, sorting and degradation > Ubiquitin mediated proteolysis.   (View pathway)

· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum.   (View pathway)

· Human Diseases > Neurodegenerative diseases > Parkinson's disease.

文献引用

1). Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles. Acta biomaterialia, 2024 (PubMed: 38729544) [IF=9.4]
2). Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis. Cell Death & Disease, 2022 (PubMed: 35641492) [IF=8.1]
3). Regulatory mechanism of perinatal nonylphenol exposure on cardiac mitochondrial autophagy and the PINK1/Parkin signaling pathway in male offspring rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2024 (PubMed: 38367424) [IF=6.7]
4). Nuanxinkang prevents the development of myocardial infarction-induced chronic heart failure by promoting PINK1/Parkin-mediated mitophagy. PHYTOMEDICINE, 2023 (PubMed: 36279758) [IF=6.7]
5). Apoptosis, Mitochondrial Autophagy, Fission, and Fusion Maintain Mitochondrial Homeostasis in Mouse Liver Under Tail Suspension Conditions. International journal of molecular sciences, 2024 (PubMed: 39456978) [IF=5.6]
6). Pyroptosis mediated by Parkin-NLRP3 negative feedback loop contributed to Parkinson's disease induced by rotenone. International immunopharmacology, 2024 (PubMed: 39549548) [IF=4.8]
7). Bergapten attenuates hemorrhagic shock induced multi-organ injury by inhibiting NLRP3 inflammasome activation and pyroptosis. International immunopharmacology, 2024 (PubMed: 39126737) [IF=4.8]
8). Regulators of calcineurin 1 deficiency attenuates tubulointerstitial fibrosis through improving mitochondrial fitness. The FASEB Journal, 2020 (PubMed: 32896034) [IF=4.4]
9). Inhibition of PTEN-induced kinase 1 autophosphorylation may assist in preventing epileptogenesis induced by pentylenetetrazol. Neurochemistry international, 2024 (PubMed: 38029887) [IF=4.4]
10). Berberine Promotes Cardiac Function by Upregulating PINK1/Parkin-Mediated Mitophagy in Heart Failure. Frontiers in Physiology, 2020 (PubMed: 33101051) [IF=4.0]

Application: WB    Species: mouse    Sample:

FIGURE 5 | Possible mechanism(s) underlying in the mitophagic regulation of berberine in Sham- and TAC-operated mice treated with or without BBR.(A)Representative gel blots for each group by western blot (n = 3)
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