pan Sodium Channel Antibody - #AF0255

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产品: pan Sodium Channel 抗体
货号: AF0255
描述: Rabbit polyclonal antibody to pan Sodium Channel
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Bovine, Horse, Sheep, Rabbit, Chicken
蛋白号: P35498 | P35499 | Q14524 | Q15858 | Q99250 | Q9NY46 | Q9UI33 | Q9UQD0 | Q9Y5Y9
RRID: AB_2833430

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
pan Sodium Channel Antibody detects endogenous levels of total pan Sodium Channel.
RRID:
AB_2833430
引用格式: Affinity Biosciences Cat# AF0255, RRID:AB_2833430.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

HBSC II;HH1;hNaN;hNE-Na;hPN3;KIAA1356;MED;NAC1;NAC2;NAC3;NENA;Neuroendocrine sodium channel;Peripheral nerve sodium channel 3;Peripheral nerve sodium channel 5;Peripheral sodium channel 1;PN1;PN3;PN5;SCN1;SCN10A;SCN11A;SCN12A;SCN1A;SCN2A;SCN2A1;SCN2A2;SCN3A;SCN4A;SCN5A;SCN8A;SCN9A;Sensory neuron sodium channel 2;SkM1;SNS2;Sodium channel protein brain I subunit alpha;Sodium channel protein brain II subunit alpha;Sodium channel protein brain III subunit alpha;Sodium channel protein cardiac muscle subunit alpha;Sodium channel protein skeletal muscle subunit alpha;Sodium channel protein type 1 subunit alpha;Sodium channel protein type 10 subunit alpha;Sodium channel protein type 11 subunit alpha;Sodium channel protein type 2 subunit alpha;Sodium channel protein type 3 subunit alpha;Sodium channel protein type 4 subunit alpha;Sodium channel protein type 5 subunit alpha;Sodium channel protein type 8 subunit alpha;Sodium channel protein type 9 subunit alpha;Sodium channel protein type II subunit alpha;Sodium channel protein type III subunit alpha;Sodium channel protein type IV subunit alpha;Sodium channel protein type IX subunit alpha;Sodium channel protein type V subunit alpha;Sodium channel protein type VIII subunit alpha;Sodium channel protein type X subunit alpha;Sodium channel protein type XI subunit alpha;Voltage-gated sodium channel subtype III;Voltage-gated sodium channel subunit alpha Nav1.1;Voltage-gated sodium channel subunit alpha Nav1.2;Voltage-gated sodium channel subunit alpha Nav1.3;Voltage-gated sodium channel subunit alpha Nav1.4;Voltage-gated sodium channel subunit alpha Nav1.5;Voltage-gated sodium channel subunit alpha Nav1.6;Voltage-gated sodium channel subunit alpha Nav1.7;Voltage-gated sodium channel subunit alpha Nav1.8;Voltage-gated sodium channel subunit alpha Nav1.9;

抗原和靶标

免疫原:

A synthesized peptide derived from human pan Sodium Channel, corresponding to a region within the internal amino acids.

基因/基因ID:
SCN4A(6329) | SCN5A(6331) | SCN9A(6335) | SCN10A(6336) | SCN3A(6328) | SCN1A(6323) | SCN2A(6326) | SCN8A(6334) | SCN11A(11280)
描述:
SCN5A This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform.

研究领域

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Nervous system > Dopaminergic synapse.

· Organismal Systems > Sensory system > Taste transduction.

文献引用

1). Cetylpyridinium chloride inhibits hepatocellular carcinoma growth and metastasis through regulating epithelial-mesenchymal transition and apoptosis. PloS one, 2024 (PubMed: 39302935) [IF=2.9]

Application: WB    Species: Human    Sample: HepG2 cells

Fig 6. CPC suppresses breast tumor growth and metastasis in vivo. A Tumor images of HepG2 cells injected subcutaneously into nude mice. B The tumor growth curves from (A) measured every 7 days (n = 6). C Tumor weights of nude mice from (A). D Representative Western blot using tumor tissues from (A) (column III). E Representative bioluminescence images (left panel) and bioluminescence analysis (right panel) of the tail vein of nude mice injected with MHCC97H-luc cells treated as in (A). F Graphic summary of CPC inhibition of HCC tumor growth and metastasis. CPC induced apoptosis and inhibited EMT by regulating the expression of apoptosis-related genes (p53, Bax, Bcl-XL, etc.) and EMT-related genes (Slug, E-cadherin, N-cadherin, and Vimentin) in a dose-dependent manner, thereby inhibiting tumor growth and metastasis. *p < 0.05, **p < 0.01.
2). EGCG Alleviates Obesity-Induced Myocardial Fibrosis in Rats by Enhancing Expression of SCN5A. Frontiers in Cardiovascular Medicine, 2022 (PubMed: 35571212) [IF=2.8]

Application: WB    Species: Rat    Sample: heart

Figure 3 RNA-seq reflect Scn5a is a hub gene of EGCG in alleviating obesity-induced myocardial fibrosis. (A) Principal Component Analysis was performed on RNA-seq; (B) The number of differently expression gene was identified by Deseq2; (C) The cross-volcano map reflects the reverse of gene expression by EGCG treatment; (D) The KEGG pathway enrichment pf reversed gene sets revealed that the change of glucose and lipid metabolism; (E) PPI network analysis showed that Scn5a was a hub gene in EGCG alleviating obesity-induced myocardial fibrosis; (F) The relative mRNA expression levels of Scn5a in the different groups; (G) The effect of EGCG on the expression of SCN5A proteins was detected by western blot with GAPDH as a loading control in the heart. (*p < 0.05, **p < 0.01, ***p < 0.001).

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