| 产品: | CD64 抗体 |
| 货号: | DF13670 |
| 描述: | Rabbit polyclonal antibody to CD64 |
| 应用: | WB IF/ICC |
| 反应: | Human, Rat |
| 分子量: | 42kDa; 43kD(Calculated). |
| 蛋白号: | P12314 |
| RRID: | AB_2846689 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13670, RRID:AB_2846689.
展开/折叠
CD64; CD64A; Fc fragment of IgG high affinity Ia receptor (CD64); Fc fragment of IgG, high affinity Ia, receptor for; Fc gamma receptor; Fc gamma receptor I A1; Fc gamma RI; Fc gamma RIA; Fc-gamma RI; Fc-gamma RIA; FCG1; FcgammaRIa; FCGR1; FCGR1_HUMAN; FCGR1A; FcRI; FLJ18345; High affinity immunoglobulin gamma Fc receptor I; IGFR1; IgG Fc receptor I; Immunoglobulin G Fc receptor I; OTTHUMP00000013913;
抗原和靶标
- P12314 FCGR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
翻译修饰 - P12314 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N59 | N-Glycosylation | Uniprot | |
| T73 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| N78 | N-Glycosylation | Uniprot | |
| Y133 | Phosphorylation | Uniprot | |
| Y137 | Phosphorylation | Uniprot | |
| Y138 | Phosphorylation | Uniprot | |
| N152 | N-Glycosylation | Uniprot | |
| N159 | N-Glycosylation | Uniprot | |
| N163 | N-Glycosylation | Uniprot | |
| N195 | N-Glycosylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| S340 | Phosphorylation | Uniprot |
研究背景
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
Phosphorylated on serine residues.
Cell membrane>Single-pass type I membrane protein.
Note: Stabilized at the cell membrane through interaction with FCER1G.
Monocyte/macrophage specific.
Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN.
Belongs to the immunoglobulin superfamily. FCGR1 family.
研究领域
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Leishmaniasis.
· Human Diseases > Infectious diseases: Bacterial > Staphylococcus aureus infection.
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
· Human Diseases > Cancers: Specific types > Acute myeloid leukemia. (View pathway)
· Human Diseases > Immune diseases > Systemic lupus erythematosus.
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
· Organismal Systems > Immune system > Hematopoietic cell lineage. (View pathway)
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
限制条款
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