(1)
(8)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13643, RRID:AB_2846662.
展开/折叠
;ASCT2; AAAT; AAAT_HUMAN; ATB(0); ATBO; Baboon M7 virus receptor; FLJ31068; M7V1; M7VS1; Neutral amino acid transporter B(0); R16; RD114/simian type D retrovirus receptor; RDR; RDRC; SLC1A5; Sodium dependent neutral amino acid transporter type 2; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 (neutral amino acid transporter), member 5; Solute carrier family 1 member 5;
抗原和靶标
- Q15758 AAAT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESVM
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q15758 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| Y38 | Phosphorylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| N212 | N-Glycosylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| S493 | Phosphorylation | Uniprot | |
| T494 | Phosphorylation | Uniprot | |
| K502 | Ubiquitination | Uniprot | |
| S503 | Phosphorylation | Uniprot | |
| K522 | Sumoylation | Uniprot | |
| K522 | Ubiquitination | Uniprot | |
| Y524 | Phosphorylation | Uniprot | |
| R525 | Methylation | Uniprot | |
| T532 | Phosphorylation | Uniprot | |
| S535 | Phosphorylation | Uniprot | |
| K537 | Acetylation | Uniprot | |
| K537 | Ubiquitination | Uniprot | |
| S539 | Phosphorylation | Uniprot |
研究背景
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development.
(Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.
(Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.
(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.
Cell membrane>Multi-pass membrane protein. Melanosome.
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.
Homotrimer (Probable). Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization.
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
研究领域
· Human Diseases > Cancers: Overview > Central carbon metabolism in cancer. (View pathway)
· Organismal Systems > Digestive system > Protein digestion and absorption.
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