SLC40A1 Antibody - #DF13561

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产品: SLC40A1 抗体
货号: DF13561
描述: Rabbit polyclonal antibody to SLC40A1
应用: WB IHC
文献验证: WB, IHC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus
蛋白号: Q9NP59
RRID: AB_2846580

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   规格 价格 库存
 50ul RMB¥ 1500 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
SLC40A1 Antibody detects endogenous levels of total SLC40A1.
RRID:
AB_2846580
引用格式: Affinity Biosciences Cat# DF13561, RRID:AB_2846580.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Ferroportin 1; Ferroportin; Ferroportin-1; FPN1; HFE4; IREG1; iron regulated gene 1; Iron regulated transporter 1; Iron-regulated transporter 1; MST079; MSTP079; MTP1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; S40A1_HUMAN; SLC11A3; SLC11A3, formerly; SLC40A1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3, formerly; solute carrier family 40 (iron-regulated transporter), member 1; Solute carrier family 40 member 1;

抗原和靶标

免疫原:

A synthesized peptide derived from human SLC40A1, corresponding to a region within N-terminal amino acids.

基因/基因ID:
SLC40A1(30061)

研究领域

· Cellular Processes > Cell growth and death > Ferroptosis.   (View pathway)

· Organismal Systems > Digestive system > Mineral absorption.

文献引用

1). Modified Fish-Skin-Collagen-Based Hydrogels with Antioxidant and Antibacterial Functions for Diabetic Wound Healing. Advanced Healthcare Materials, 2025 [IF=9.6]
2). Bone morphogenetic protein 4 derived from the cerebrospinal fluid in patients with postherpetic neuralgia induces allodynia via the crosstalk between microglia and astrocyte. Brain, behavior, and immunity, 2024 (PubMed: 38735405) [IF=8.8]
3). Voluntary exercise alleviates neural functional deficits in Parkinson's disease mice by inhibiting microglial ferroptosis via SLC7A11/ALOX12 axis. NPJ Parkinson's disease, 2025 (PubMed: 40122927) [IF=8.7]
4). Defective ferritinophagy and imbalanced iron metabolism in PBDE-47-triggered neuronal ferroptosis and salvage by Canolol. The Science of the total environment, 2024 (PubMed: 38750757) [IF=8.2]
5). Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury. Free radical biology & medicine, 2023 (PubMed: 36805045) [IF=7.1]
6). GSK-3β-dependent Nrf2 antioxidant response modulates ferroptosis of lens epithelial cells in age-related cataract. Free Radical Biology and Medicine, 2023 (PubMed: 37156294) [IF=7.1]
7). Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2/System xc-/GPX4 axis. Biomedicine & Pharmacotherapy, 2023 (PubMed: 36379122) [IF=6.9]
8). Protective benefits of salvianic acid A against retinal iron overload by inhibition of ferroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 (PubMed: 37429233) [IF=6.9]
9). Erythropoietin inhibits ferroptosis and ameliorates neurological function after spinal cord injury. Neural Regeneration Research, 2023 (PubMed: 36204858) [IF=5.9]

Application: WB    Species: Rat    Sample: spinal cord

Figure 3 EPO regulates the expression of ferroptotic biomarkers after SCI. (A) Western blot of the indicated proteins in injured tissues from the treatment groups. (B–H) Quantitative analysis of Tfr, Fpn, Fth, Acsl4 and 4-Hne protein expression at 14 dpi. Gapdh was used as the reference protein. (I, J) Quantitative reverse transcription polymerase chain reaction results of xCT and Gpx4 mRNA extracted from injured tissue at 7 dpi. β-Actin mRNA was used as the reference gene. (K) Quantitative analysis of reduced GSH from injured tissue at 7 dpi. All data are expressed as the mean ± SD (n = 5 in each group). *P < 0.05, **P < 0.01, ***P < 0.001 (one-way analysis of variance followed by Dunnett’s multiple comparisons test). 4-Hne: 4-Hydroxynonenal; Acsl4: acyl-coenzyme A synthetase long chain family member 4; dpi: day(s) post injury; EPO: erythropoietin; Fpn: ferroportin or solute carrier family 40 member 1; Fth: ferritin heavy chain; Gapdh: glyceraldehyde-3-phosphate dehydrogenase; Gpx4: glutathione peroxidase 4; GSH: glutathione; ns: not significant; SCI: spinal cord injury; Tfr: transferrin receptor; xCT: the solute carrier family 7 member 11.
10). Moderate static magnetic field regulates iron metabolism and salvage bone loss caused by iron accumulation. Journal of orthopaedic translation, 2025 (PubMed: 40171108) [IF=5.9]
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