产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13558, RRID:AB_2846577.
展开/折叠
Fermitin family homolog 3; Fermitin family member 3; FERMT3; Kind3; Kindlin 3; Kindlin-3; Kindlin3; MGC10966; MIG 2; MIG2 like protein; MIG2-like protein; MIG2B; Unc 112 related protein 2; Unc-112-related protein 2; UNC112C; URP2; URP2_HUMAN; URP2SF;
抗原和靶标
Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
- Q86UX7 URP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGMKTASGDYIDSSWELRVFVGEEDPEAESVTLRVTGESHIGGVLLKIVEQINRKQDWSDHAIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRALRLRASFSQPLFQAVAAICRLLSIRHPEELSLLRAPEKKEKKKKEKEPEEELYDLSKVVLAGGVAPALFRGMPAHFSDSAQTEACYHMLSRPQPPPDPLLLQRLPRPSSLSDKTQLHSRWLDSSRCLMQQGIKAGDALWLRFKYYSFFDLDPKTDPVRLTQLYEQARWDLLLEEIDCTEEEMMVFAALQYHINKLSQSGEVGEPAGTDPGLDDLDVALSNLEVKLEGSAPTDVLDSLTTIPELKDHLRIFRIPRRPRKLTLKGYRQHWVVFKETTLSYYKSQDEAPGDPIQQLNLKGCEVVPDVNVSGQKFCIKLLVPSPEGMSEIYLRCQDEQQYARWMAGCRLASKGRTMADSSYTSEVQAILAFLSLQRTGSGGPGNHPHGPDASAEGLNPYGLVAPRFQRKFKAKQLTPRILEAHQNVAQLSLAEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEILGIANNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGHEAF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q86UX7 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K5 | Ubiquitination | Uniprot | |
| T6 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| Y11 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| Y162 | Phosphorylation | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| K242 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| S345 | Phosphorylation | Uniprot | |
| K353 | Ubiquitination | Uniprot | |
| T369 | Phosphorylation | Uniprot | |
| K371 | Methylation | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| K419 | Acetylation | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| S428 | Phosphorylation | Uniprot | |
| T482 | Phosphorylation | Uniprot | |
| S484 | Phosphorylation | Uniprot | |
| Y504 | Phosphorylation | Uniprot | |
| K516 | Methylation | Uniprot | |
| K567 | Ubiquitination | Uniprot | |
| K590 | Ubiquitination | Uniprot | |
| T591 | Phosphorylation | Uniprot | |
| S595 | Phosphorylation | Uniprot | |
| S622 | Phosphorylation | Uniprot | |
| S625 | Phosphorylation | Uniprot | |
| S642 | Phosphorylation | Uniprot |
研究背景
Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).
Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.
Cell projection>Podosome.
Note: Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.
Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
Interacts with ITGB1, ITGB2 and ITGB3 (via cytoplasmic tails).
The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.
Belongs to the kindlin family.
研究领域
· Organismal Systems > Immune system > Platelet activation. (View pathway)
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