KCNN2 Antibody - #DF13499

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产品: KCNN2 抗体
货号: DF13499
描述: Rabbit polyclonal antibody to KCNN2
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
分子量: 63kDa; 64kD(Calculated).
蛋白号: Q9H2S1
RRID: AB_2846518

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
IF/ICC 1:100-1:500, WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
KCNN2 Antibody detects endogenous levels of total KCNN2.
RRID:
AB_2846518
引用格式: Affinity Biosciences Cat# DF13499, RRID:AB_2846518.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

抗原和靶标

免疫原:
Uniprot:

Q9H2S1(KCNN2_HUMAN) >>Visit HPA database.

基因/基因ID:
KCNN2(3781)
表达:
Q9H2S1 KCNN2_HUMAN:

Expressed in atrial myocytes (at protein level). Widely expressed.

序列:
MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS

翻译修饰 - Q9H2S1 作为底物

Site PTM Type Enzyme
Y6 Phosphorylation
S15 Phosphorylation
S18 Phosphorylation
T90 Phosphorylation
Y119 Phosphorylation
S135 Phosphorylation P17612 (PRKACA)
K293 Ubiquitination
K401 Ubiquitination
S464 Phosphorylation P17612 (PRKACA)
K466 Sumoylation
K484 Acetylation
T516 Phosphorylation
T531 Phosphorylation
S562 Phosphorylation
R566 Methylation
S567 Phosphorylation P17612 (PRKACA)
S568 Phosphorylation P17612 (PRKACA)
S569 Phosphorylation P17612 (PRKACA)
T574 Phosphorylation

研究背景

功能:

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

细胞定位:

Membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in atrial myocytes (at protein level). Widely expressed.

亚基结构:

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

蛋白家族:

Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.

研究领域

· Organismal Systems > Nervous system > Serotonergic synapse.

· Organismal Systems > Endocrine system > Insulin secretion.   (View pathway)

文献引用

1). Roles of nucleus accumbens shell small-conductance calcium-activated potassium channels in the conditioned fear freezing. Journal of Psychiatric Research, 2023 (PubMed: 37216772) [IF=3.7]

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