15 Lipoxygenase 1 Antibody - #DF13494

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产品: 15 Lipoxygenase 1 抗体
货号: DF13494
描述: Rabbit polyclonal antibody to 15 Lipoxygenase 1
应用: WB
文献验证:
反应: Human, Rat
预测: Pig, Bovine, Sheep, Rabbit, Dog
蛋白号: P16050
RRID: AB_2846513

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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实验方案
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IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Rat
克隆:
Polyclonal
特异性:
15 Lipoxygenase 1 Antibody detects endogenous levels of total 15 Lipoxygenase 1.
RRID:
AB_2846513
引用格式: Affinity Biosciences Cat# DF13494, RRID:AB_2846513.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

15 lipoxygenase 1; 15 LIPOXYGENASE RETICULOCYTE ARACHIDONATE; 15 LOX; 15 LOX 1; 15-LOX; 15LOX 1; ALOX15; Arachidonate 15 lipoxygenase; Arachidonate 15-lipoxygenase; Arachidonate omega 6 lipoxygenase; Arachidonate omega-6 lipoxygenase; LOG15; LOX15_HUMAN;

抗原和靶标

免疫原:

A synthesized peptide derived from human 15 Lipoxygenase 1, corresponding to a region within C-terminal amino acids.

基因/基因ID:
ALOX15(246)

研究领域

· Cellular Processes > Cell growth and death > Ferroptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Metabolism > Lipid metabolism > Arachidonic acid metabolism.

· Metabolism > Lipid metabolism > Linoleic acid metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > Serotonergic synapse.

文献引用

1). Nme8 is essential for protection against chemotherapy drug cisplatin-induced male reproductive toxicity in mice. Cell death & disease, 2024 (PubMed: 39368984) [IF=8.1]
2). Regulation of optimized new Shengmai powder on cardiomyocyte apoptosis and ferroptosis in ischemic heart failure rats: The mediating role of phosphatidylinositol-3-kinase/protein kinase B/tumor protein 53 signaling pathway. Journal of ethnopharmacology, 2024 (PubMed: 38692417) [IF=4.8]
3). Identification of Genes Reveals the Mechanism of Cell Ferroptosis in Diabetic Nephropathy. Frontiers in Physiology, 2022 (PubMed: 35721535) [IF=4.0]

Application: IF/ICC    Species: Mice    Sample:

FIGURE 5 Expression of ALOX15 mRNA and protein in DN. (A) Real-time PCR assay of ALOX15 mRNA in STZ-induced diabetes mice models. (B) Real-time PCR assay of ALOX15 mRNA in db/db mice models. (C) IHC assay of ALOX15 protein expression on kidney tissues of STZ-induced diabetic mice models. Scale bar = 20 μm. (D) IHC assay of ALOX15 protein expression on kidney tissues of db/db mice models. Scale bar = 20 μm. (E) IHC assay of ALOX15 protein expression on human renal biopsy tissues. Scale bar = 20 μm. (F) Immunofluorescence double staining of GPX4 and ALOX15 protein co-expression on mice glomerulus. Scale bar = 20 μm. Results represented the mean ± SEM for six samples/group. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. NC; ### p < 0.001 vs. EDN. NC normal control; DN diabetic nephropathy; EDN early DN; ADN advanced DN; STZ streptozotocin; IHC immunohistochemical staining.
4). CircRNA 06209 inhibits cataract development by sponging miR-6848-5p and regulating ALOX15 expression. Experimental eye research, 2023 (PubMed: 37673368) [IF=3.0]

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