(1)
(3)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13249, RRID:AB_2846268.
展开/折叠
Beta GR; Beta-glucan receptor; BGR; C type calcium dependent carbohydrate recognition domain lectin superfamily member 12; C type lectin domain family 7 member a; C-type lectin domain family 7 member A; C-type lectin superfamily member 12; CANDF4; CLC7A_HUMAN; CLEC7A; CLEC7A protein; Clecsf12; DC-associated C-type lectin 1; Dectin 1; DECTIN 1 receptor; Dectin-1; Dectin1; Dendritic cell associated C type lectin 1; Dendritic cell-associated C-type lectin 1; Lectin like receptor 1; Putative transmembrane protein dectin 1;
抗原和靶标
A synthesized peptide derived from human Dectin-1, corresponding to a region within the internal amino acids.
Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
- Q9BXN2 CLC7A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEYHPDLENLDEDGYTQLHFDSQSNTRIAVVSEKGSCAASPPWRLIAVILGILCLVILVIAVVLGTMAIWRSNSGSNTLENGYFLSRNKENHSQPTQSSLEDSVTPTKAVKTTGVLSSPCPPNWIIYEKSCYLFSMSLNSWDGSKRQCWQLGSNLLKIDSSNELGFIVKQVSSQPDNSFWIGLSRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSPNCVWIHVSVIYDQLCSVPSYSICEKKFSM
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).
Phosphorylated on tyrosine residues in response to glucan binding.
Cell membrane>Single-pass type II membrane protein.
Cytoplasm.
Cytoplasm.
Cytoplasm.
Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
研究领域
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
文献引用
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